FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2126768469> ?p ?o ?g. }

• W2126768469 endingPage "E262" @default.
• W2126768469 startingPage "E255" @default.
• W2126768469 abstract "To assess the dynamics of taurine metabolism in vivo, two sets of studies were carried out in healthy volunteers. First, pilot studies were carried in a single human subject to determine the time course of plasma and whole blood isotope enrichment over the course of an 8-h, unprimed continuous infusion of [1,2-(13)C(2)]taurine. Second, five healthy adult males received two tracer infusions on separate days and in randomized order: 1) a 6-h continuous infusion of [1,2-(13)C(2)]taurine (3.1 +/- 0.2 micromol x kg(-1) x h(-1)) and 2) a bolus injection of [(13)C(2)]taurine (3.0 +/- 0.1 micromol/kg). Isotope enrichments in plasma and whole blood taurine were determined by gas chromatography-mass spectrometry. The pilot experiments allowed us to establish that steady-state isotope enrichment was reached in plasma and whole blood by the 5th h of tracer infusion. The plateau enrichment reached in whole blood was lower than that obtained in plasma taurine (P < 0.02). In the second set of studies, the appearance rate (R(a)) of plasma taurine, determined from continuous infusion studies was 31.8 +/- 3.1 micromol x kg(-1) x h(-1). After a bolus injection of tracer, the enrichment decay over the subsequent 2 h was best fitted by a two-exponential curve. Taurine R(a) was approximately 85% higher when determined using the bolus injection technique compared with continuous infusion of tracer. We conclude that 1) taurine R(a) into plasma is very low in healthy postabsorptive humans, and, due to taurine compartmentation between the extra- and intracellular milieus, may represent only interorgan taurine transfer and merely a small fraction of whole body taurine turnover; and 2) the bolus injection technique may overestimate taurine appearance into plasma. Further studies are warranted to determine whether alterations in bile taurine dynamics affect taurine R(a)." @default.
• W2126768469 created "2016-06-24" @default.
• W2126768469 creator A5005624631 @default.
• W2126768469 creator A5016271900 @default.
• W2126768469 creator A5046224464 @default.
• W2126768469 creator A5054309690 @default.
• W2126768469 creator A5079775540 @default.
• W2126768469 creator A5081141495 @default.
• W2126768469 creator A5091324781 @default.
• W2126768469 creator A5091643956 @default.
• W2126768469 date "2004-08-01" @default.
• W2126768469 modified "2023-09-26" @default.
• W2126768469 title "Taurine kinetics assessed using [1,2-¹³C₂]taurine in healthy adult humans" @default.
• W2126768469 cites W1271996592 @default.
• W2126768469 cites W1533282010 @default.
• W2126768469 cites W1610326563 @default.
• W2126768469 cites W1640072451 @default.
• W2126768469 cites W1754402125 @default.
• W2126768469 cites W1834298935 @default.
• W2126768469 cites W1838845567 @default.
• W2126768469 cites W1865864547 @default.
• W2126768469 cites W1893563219 @default.
• W2126768469 cites W1935064934 @default.
• W2126768469 cites W1967463743 @default.
• W2126768469 cites W1980404546 @default.
• W2126768469 cites W1984151152 @default.
• W2126768469 cites W1985865398 @default.
• W2126768469 cites W1996688795 @default.
• W2126768469 cites W2014132326 @default.
• W2126768469 cites W2021711907 @default.
• W2126768469 cites W2027890191 @default.
• W2126768469 cites W2034743887 @default.
• W2126768469 cites W2042316825 @default.
• W2126768469 cites W2050601531 @default.
• W2126768469 cites W2054109617 @default.
• W2126768469 cites W2054885423 @default.
• W2126768469 cites W2086973717 @default.
• W2126768469 cites W2087125620 @default.
• W2126768469 cites W2087668297 @default.
• W2126768469 cites W2091101612 @default.
• W2126768469 cites W2100421389 @default.
• W2126768469 cites W2110275383 @default.
• W2126768469 cites W2116123190 @default.
• W2126768469 cites W2117516067 @default.
• W2126768469 cites W2124261589 @default.
• W2126768469 cites W2128807339 @default.
• W2126768469 cites W2140406164 @default.
• W2126768469 cites W2145807912 @default.
• W2126768469 cites W2159007574 @default.
• W2126768469 cites W2165382247 @default.
• W2126768469 cites W2168973762 @default.
• W2126768469 cites W2177909750 @default.
• W2126768469 cites W2253609735 @default.
• W2126768469 cites W2327802890 @default.
• W2126768469 cites W2330496924 @default.
• W2126768469 cites W2341154236 @default.
• W2126768469 cites W2400782206 @default.
• W2126768469 cites W315706058 @default.
• W2126768469 cites W4241465559 @default.
• W2126768469 cites W4302582621 @default.
• W2126768469 doi "https://doi.org/10.1152/ajpendo.00333.2003" @default.
• W2126768469 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15010336" @default.
• W2126768469 hasPublicationYear "2004" @default.
• W2126768469 type Work @default.
• W2126768469 sameAs 2126768469 @default.
• W2126768469 citedByCount "16" @default.
• W2126768469 countsByYear W21267684692012 @default.
• W2126768469 countsByYear W21267684692014 @default.
• W2126768469 countsByYear W21267684692017 @default.
• W2126768469 countsByYear W21267684692018 @default.
• W2126768469 countsByYear W21267684692023 @default.
• W2126768469 crossrefType "journal-article" @default.
• W2126768469 hasAuthorship W2126768469A5005624631 @default.
• W2126768469 hasAuthorship W2126768469A5016271900 @default.
• W2126768469 hasAuthorship W2126768469A5046224464 @default.
• W2126768469 hasAuthorship W2126768469A5054309690 @default.
• W2126768469 hasAuthorship W2126768469A5079775540 @default.
• W2126768469 hasAuthorship W2126768469A5081141495 @default.
• W2126768469 hasAuthorship W2126768469A5091324781 @default.
• W2126768469 hasAuthorship W2126768469A5091643956 @default.
• W2126768469 hasConcept C121332964 @default.
• W2126768469 hasConcept C126322002 @default.
• W2126768469 hasConcept C134018914 @default.
• W2126768469 hasConcept C1621761 @default.
• W2126768469 hasConcept C164304813 @default.
• W2126768469 hasConcept C185592680 @default.
• W2126768469 hasConcept C2779701627 @default.
• W2126768469 hasConcept C43376680 @default.
• W2126768469 hasConcept C43617362 @default.
• W2126768469 hasConcept C515207424 @default.
• W2126768469 hasConcept C55493867 @default.
• W2126768469 hasConcept C62520636 @default.
• W2126768469 hasConcept C71924100 @default.
• W2126768469 hasConceptScore W2126768469C121332964 @default.
• W2126768469 hasConceptScore W2126768469C126322002 @default.
• W2126768469 hasConceptScore W2126768469C134018914 @default.
• W2126768469 hasConceptScore W2126768469C1621761 @default.
• W2126768469 hasConceptScore W2126768469C164304813 @default.

• next