FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2126770148> ?p ?o ?g. }

• W2126770148 endingPage "4855" @default.
• W2126770148 startingPage "4855" @default.
• W2126770148 abstract "Low oxygen tensions experienced in various pathological and physiological conditions are a major stimulus for angiogenesis. Hypoxic conditions play a critical role in regulating cellular behaviour including migration, proliferation and differentiation. This study introduces the use of a microfluidic device that allows for the control of oxygen tension for the study of different three-dimensional (3D) cell cultures for various applications. The device has a central 3D gel region acting as an external cellular matrix, flanked by media channels. On each side, there is a peripheral gas channel through which suitable gas mixtures are supplied to establish a uniform oxygen tension or gradient within the device. The effects of various parameters, such as gas and media flow rates, device thickness, and diffusion coefficients of oxygen were examined using numerical simulations to determine the characteristics of the microfluidic device. A polycarbonate (PC) film with a low oxygen diffusion coefficient was embedded in the device in proximity above the channels to prevent oxygen diffusion from the incubator environment into the polydimethylsiloxane (PDMS) device. The oxygen tension in the device was then validated experimentally using a ruthenium-coated (Ru-coated) oxygen-sensing glass cover slip which confirmed the establishment of low uniform oxygen tensions (<3%) or an oxygen gradient across the gel region. To demonstrate the utility of the microfluidic device for cellular experiments under hypoxic conditions, migratory studies of MDA-MB-231 human breast cancer cells were performed. The microfluidic device allowed for imaging cellular migration with high-resolution, exhibiting an enhanced migration in hypoxia in comparison to normoxia. This microfluidic device presents itself as a promising platform for the investigation of cellular behaviour in a 3D gel scaffold under varying hypoxic conditions." @default.
• W2126770148 created "2016-06-24" @default.
• W2126770148 creator A5004209082 @default.
• W2126770148 creator A5013479187 @default.
• W2126770148 creator A5033640494 @default.
• W2126770148 creator A5047618524 @default.
• W2126770148 creator A5061434731 @default.
• W2126770148 creator A5065934461 @default.
• W2126770148 date "2012-01-01" @default.
• W2126770148 modified "2023-10-02" @default.
• W2126770148 title "A novel microfluidic platform for high-resolution imaging of a three-dimensional cell culture under a controlled hypoxic environment" @default.
• W2126770148 cites W122518273 @default.
• W2126770148 cites W1565998422 @default.
• W2126770148 cites W1970550910 @default.
• W2126770148 cites W1972002559 @default.
• W2126770148 cites W1978496495 @default.
• W2126770148 cites W1979414396 @default.
• W2126770148 cites W1986543940 @default.
• W2126770148 cites W1993805976 @default.
• W2126770148 cites W1996163778 @default.
• W2126770148 cites W2004875910 @default.
• W2126770148 cites W2006835321 @default.
• W2126770148 cites W2013944399 @default.
• W2126770148 cites W2016915024 @default.
• W2126770148 cites W2017065846 @default.
• W2126770148 cites W2025789062 @default.
• W2126770148 cites W2026552771 @default.
• W2126770148 cites W2029527263 @default.
• W2126770148 cites W2045911112 @default.
• W2126770148 cites W2046411237 @default.
• W2126770148 cites W2048010887 @default.
• W2126770148 cites W2052234083 @default.
• W2126770148 cites W2054251094 @default.
• W2126770148 cites W2056259865 @default.
• W2126770148 cites W2062317385 @default.
• W2126770148 cites W2062548671 @default.
• W2126770148 cites W2063590950 @default.
• W2126770148 cites W2071702582 @default.
• W2126770148 cites W2084037323 @default.
• W2126770148 cites W2088004044 @default.
• W2126770148 cites W2092353698 @default.
• W2126770148 cites W2094082525 @default.
• W2126770148 cites W2094576343 @default.
• W2126770148 cites W2094802445 @default.
• W2126770148 cites W2099635527 @default.
• W2126770148 cites W2103577913 @default.
• W2126770148 cites W2110259036 @default.
• W2126770148 cites W2119848853 @default.
• W2126770148 cites W2125257427 @default.
• W2126770148 cites W2131638827 @default.
• W2126770148 cites W2135180965 @default.
• W2126770148 cites W2135566644 @default.
• W2126770148 cites W2136419149 @default.
• W2126770148 cites W2150482005 @default.
• W2126770148 cites W2152059298 @default.
• W2126770148 cites W2171803108 @default.
• W2126770148 cites W2175411730 @default.
• W2126770148 cites W2285724889 @default.
• W2126770148 doi "https://doi.org/10.1039/c2lc40306d" @default.
• W2126770148 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4086303" @default.
• W2126770148 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23023115" @default.
• W2126770148 hasPublicationYear "2012" @default.
• W2126770148 type Work @default.
• W2126770148 sameAs 2126770148 @default.
• W2126770148 citedByCount "121" @default.
• W2126770148 countsByYear W21267701482013 @default.
• W2126770148 countsByYear W21267701482014 @default.
• W2126770148 countsByYear W21267701482015 @default.
• W2126770148 countsByYear W21267701482016 @default.
• W2126770148 countsByYear W21267701482017 @default.
• W2126770148 countsByYear W21267701482018 @default.
• W2126770148 countsByYear W21267701482019 @default.
• W2126770148 countsByYear W21267701482020 @default.
• W2126770148 countsByYear W21267701482021 @default.
• W2126770148 countsByYear W21267701482022 @default.
• W2126770148 countsByYear W21267701482023 @default.
• W2126770148 crossrefType "journal-article" @default.
• W2126770148 hasAuthorship W2126770148A5004209082 @default.
• W2126770148 hasAuthorship W2126770148A5013479187 @default.
• W2126770148 hasAuthorship W2126770148A5033640494 @default.
• W2126770148 hasAuthorship W2126770148A5047618524 @default.
• W2126770148 hasAuthorship W2126770148A5061434731 @default.
• W2126770148 hasAuthorship W2126770148A5065934461 @default.
• W2126770148 hasBestOaLocation W21267701482 @default.
• W2126770148 hasConcept C12554922 @default.
• W2126770148 hasConcept C136229726 @default.
• W2126770148 hasConcept C171250308 @default.
• W2126770148 hasConcept C178790620 @default.
• W2126770148 hasConcept C185592680 @default.
• W2126770148 hasConcept C192562407 @default.
• W2126770148 hasConcept C2779849746 @default.
• W2126770148 hasConcept C2993207723 @default.
• W2126770148 hasConcept C540031477 @default.
• W2126770148 hasConcept C71924100 @default.
• W2126770148 hasConcept C8673954 @default.
• W2126770148 hasConcept C86803240 @default.
• W2126770148 hasConcept C89169090 @default.
• W2126770148 hasConceptScore W2126770148C12554922 @default.

• next