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• W2126775039 abstract "Objective. To investigate whether anticardiolipin antibodies (aCL) in patients with systemic lupus erythematosus (SLE) bind to β2-glycoprotein I (β2GPI), and to search for a relationship between the presence of IgG and/or IgM anti-β2GPI antibody and clinical manifestations in SLE patients. Methods. IgG and IgM anti-β2GPI in 308 Japanese SLE patients were measured using phospholipid-independent enzyme immunoassays. Relationships to clinical histories and to various laboratory data were examined. Results. The values of anti-β2GPI and aCL, as measured by conventional enzyme immunoassay, showed a strong correlation, but the anti-β2GPI assay was more useful in distinguishing β2GPI-dependent aCL from β2GPI-independent aCL. The presence of IgG anti-β2GPI was associated with an increased frequency of a history of thrombosis. Comparisons of various laboratory data suggested that the titer of anti-β2GPI may fluctuate with disease activity. Conclusion. The results suggest that pathogenic aCL is directed against structurally altered β2GPI and that enzyme immunoassay for anti-β2GPI may prove useful in evaluating the risk of thrombosis and monitoring the clinical course in patients with SLE." @default.
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• W2126775039 date "1996-09-01" @default.
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• W2126775039 title "Antibodies to β2-glycoprotein I and clinical manifestations in patients with systemic lupus erythematosus" @default.
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• W2126775039 doi "https://doi.org/10.1002/art.1780390905" @default.
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