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• W2126782912 abstract "With the purpose of investigating the pathophysiology of changes in the R wave after exercise and its relationship with left ventricular function, we studied 44 patients with coronary heart disease. They were classified into the following three groups: group A, 11 patients with angina pectoris and no prior myocardial infarction; group B, 18 patients with angina pectoris and prior myocardial infarction; and group C, 15 patients with prior myocardial infarction but no angina. All patients performed two exercise tests; one was a control test, and the other was performed after the sublingual administration of 5 mg of isosorbide dinitrate. In group A, variations in the R-wave voltage in control test and in the test after isosorbide dinitrate were 1.5 ± 0.8 mm and –1.2 ± 0.9 mm (P < 0.05), respectively. In group B, results were 1.2 ± 0.7 mm on the control test and –0.7 ± 0.6 mm after isosorbide dinitrate (P < 0.002), and in group C were –1.6 ± 1.2 mm on the control test and –0.7 ± 0.7 mm after isosorbide dinitrate (not significant). Thus, the two groups of patients with angina showed an increase of the R-wave after exercise in the control test but a decrease after the administration of nitrates, whereas the patients without angina showed a reduced R-wave after exercise both before and after the administration of nitrates (like normal subjects). This study suggests that ischemic ventricular dysfunction with exercise results in an increase in the R-wave, while exercise after nitrates results in a decrease in the R-wave consistent with less or no ventricular dysfunction due to nitrate therapy. With the purpose of investigating the pathophysiology of changes in the R wave after exercise and its relationship with left ventricular function, we studied 44 patients with coronary heart disease. They were classified into the following three groups: group A, 11 patients with angina pectoris and no prior myocardial infarction; group B, 18 patients with angina pectoris and prior myocardial infarction; and group C, 15 patients with prior myocardial infarction but no angina. All patients performed two exercise tests; one was a control test, and the other was performed after the sublingual administration of 5 mg of isosorbide dinitrate. In group A, variations in the R-wave voltage in control test and in the test after isosorbide dinitrate were 1.5 ± 0.8 mm and –1.2 ± 0.9 mm (P < 0.05), respectively. In group B, results were 1.2 ± 0.7 mm on the control test and –0.7 ± 0.6 mm after isosorbide dinitrate (P < 0.002), and in group C were –1.6 ± 1.2 mm on the control test and –0.7 ± 0.7 mm after isosorbide dinitrate (not significant). Thus, the two groups of patients with angina showed an increase of the R-wave after exercise in the control test but a decrease after the administration of nitrates, whereas the patients without angina showed a reduced R-wave after exercise both before and after the administration of nitrates (like normal subjects). This study suggests that ischemic ventricular dysfunction with exercise results in an increase in the R-wave, while exercise after nitrates results in a decrease in the R-wave consistent with less or no ventricular dysfunction due to nitrate therapy." @default.
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• W2126782912 date "1981-08-01" @default.
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• W2126782912 title "Effects of Nitrates on R-Wave Variations after Exercise in Coronary Heart Disease" @default.
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• W2126782912 doi "https://doi.org/10.1378/chest.80.2.137" @default.
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