FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2126789114> ?p ?o ?g. }

• W2126789114 endingPage "88" @default.
• W2126789114 startingPage "78" @default.
• W2126789114 abstract "Vertebrate gamma-interferon inducible lysosomal thiol reductase (GILT) is an IFN-γ-inducible protein and is involved in MHCII-restricted antigen processing and cross-presentation of MHCI-restricted antigens in adaptive immunity. Outside of the endocytic MHC pathway, GILT regulates the cellular redox state, inhibits T cell activation, neutralizes extracellular pathogens and is also a host factor of some bacterial pathogens. In this report, we isolated and characterized three divergent GILT-like genes, GILT1, GILT2 and GILT3, which share only 30.9-40.4% identities in a crustacean mud crab Scylla paramamosain. Whilst the crab GILT1 and GILT3 possess four and five exons, respectively, the GILT2 is intronless, suggesting that GILT2 may arise from a recent retroposition event. The invertebrate GILT-like genes have diverse gene organizations and may be evolved in a species/lineage-specific manner as suggested by phylogenetic tree analysis. The amino acid sequences equivalent to human mature GILT are well conserved, including the GILT signature and nine of the ten cysteine residues that potentially form 5 disulfide bonds in human GILT, across the animal kingdom. However, most invertebrate GILT-like molecules lack the human-type N-terminal propeptide, as well as the human-type C-terminal with a conserved cysteine residue, suggesting differences in post translational processing and mode of action. All the three GILT-like genes are highly expressed in the hepatopancreas and up-regulated by pathogenic bacterial infection suggesting a role in immune defense against bacterial diseases. This study may provide the basis for further investigation of the expanding functions of GILT-like molecules in immunity and other physiological processes in mud crabs and other animals." @default.
• W2126789114 created "2016-06-24" @default.
• W2126789114 creator A5005240568 @default.
• W2126789114 creator A5013491559 @default.
• W2126789114 creator A5020951713 @default.
• W2126789114 creator A5026270755 @default.
• W2126789114 creator A5030110760 @default.
• W2126789114 creator A5051875515 @default.
• W2126789114 creator A5056819953 @default.
• W2126789114 creator A5074750162 @default.
• W2126789114 creator A5091037399 @default.
• W2126789114 date "2015-10-01" @default.
• W2126789114 modified "2023-10-14" @default.
• W2126789114 title "Identification of three IFN-γ inducible lysosomal thiol reductase ( GILT )-like genes in mud crab Scylla paramamosain with distinct gene organizations and patterns of expression" @default.
• W2126789114 cites W1488025053 @default.
• W2126789114 cites W1503855102 @default.
• W2126789114 cites W1585953759 @default.
• W2126789114 cites W1596387343 @default.
• W2126789114 cites W1648647035 @default.
• W2126789114 cites W1915462554 @default.
• W2126789114 cites W1963223912 @default.
• W2126789114 cites W1964335421 @default.
• W2126789114 cites W1967593956 @default.
• W2126789114 cites W1970675162 @default.
• W2126789114 cites W1972973858 @default.
• W2126789114 cites W1973613852 @default.
• W2126789114 cites W1975267384 @default.
• W2126789114 cites W1975538735 @default.
• W2126789114 cites W1980812273 @default.
• W2126789114 cites W1982291062 @default.
• W2126789114 cites W1983624690 @default.
• W2126789114 cites W1987111655 @default.
• W2126789114 cites W1987835395 @default.
• W2126789114 cites W1987942447 @default.
• W2126789114 cites W1988032016 @default.
• W2126789114 cites W1992122154 @default.
• W2126789114 cites W1992908723 @default.
• W2126789114 cites W1994136017 @default.
• W2126789114 cites W1997833542 @default.
• W2126789114 cites W2001897186 @default.
• W2126789114 cites W2008208329 @default.
• W2126789114 cites W2010558230 @default.
• W2126789114 cites W2013362488 @default.
• W2126789114 cites W2015394381 @default.
• W2126789114 cites W2031190791 @default.
• W2126789114 cites W2032097154 @default.
• W2126789114 cites W2036728748 @default.
• W2126789114 cites W2038142305 @default.
• W2126789114 cites W2038431803 @default.
• W2126789114 cites W2043868903 @default.
• W2126789114 cites W2047082254 @default.
• W2126789114 cites W2048313037 @default.
• W2126789114 cites W2049743745 @default.
• W2126789114 cites W2064854218 @default.
• W2126789114 cites W2068181993 @default.
• W2126789114 cites W2071991488 @default.
• W2126789114 cites W2077529270 @default.
• W2126789114 cites W2080048333 @default.
• W2126789114 cites W2083401918 @default.
• W2126789114 cites W2084562857 @default.
• W2126789114 cites W2086015935 @default.
• W2126789114 cites W2089496505 @default.
• W2126789114 cites W2094201044 @default.
• W2126789114 cites W2094267156 @default.
• W2126789114 cites W2095724872 @default.
• W2126789114 cites W2097091317 @default.
• W2126789114 cites W2127230663 @default.
• W2126789114 cites W2137696272 @default.
• W2126789114 cites W2147838733 @default.
• W2126789114 cites W2152207030 @default.
• W2126789114 cites W2160243018 @default.
• W2126789114 cites W2163064116 @default.
• W2126789114 cites W2171194410 @default.
• W2126789114 doi "https://doi.org/10.1016/j.gene.2015.06.006" @default.
• W2126789114 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26051415" @default.
• W2126789114 hasPublicationYear "2015" @default.
• W2126789114 type Work @default.
• W2126789114 sameAs 2126789114 @default.
• W2126789114 citedByCount "18" @default.
• W2126789114 countsByYear W21267891142015 @default.
• W2126789114 countsByYear W21267891142016 @default.
• W2126789114 countsByYear W21267891142017 @default.
• W2126789114 countsByYear W21267891142018 @default.
• W2126789114 countsByYear W21267891142019 @default.
• W2126789114 countsByYear W21267891142021 @default.
• W2126789114 countsByYear W21267891142022 @default.
• W2126789114 countsByYear W21267891142023 @default.
• W2126789114 crossrefType "journal-article" @default.
• W2126789114 hasAuthorship W2126789114A5005240568 @default.
• W2126789114 hasAuthorship W2126789114A5013491559 @default.
• W2126789114 hasAuthorship W2126789114A5020951713 @default.
• W2126789114 hasAuthorship W2126789114A5026270755 @default.
• W2126789114 hasAuthorship W2126789114A5030110760 @default.
• W2126789114 hasAuthorship W2126789114A5051875515 @default.
• W2126789114 hasAuthorship W2126789114A5056819953 @default.
• W2126789114 hasAuthorship W2126789114A5074750162 @default.
• W2126789114 hasAuthorship W2126789114A5091037399 @default.
• W2126789114 hasConcept C104317684 @default.

• next