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• W2126834460 abstract "s / Thrombosis Research 127 (2011) S123–S150 S125 O.04b Effect of the dose of oral treatment with 17beta-estradiol associated with dydrogesterone on thrombin generation in healthy postmenopausal women: a randomized double-blind placebo-controlled study G. Gerotziafas *, V. Galea, A. Rousseau, D. Torchin, K.F. Zannad, K. Lacut, J. Demolis, T. Simon, I. Elalamy. ER2UPMC, Faculte de Medecine Pierre et Marie Curie, Universite Paris 6, Hopital Tenon, APHP, Paris, Clinical research Unit, Department of Clinical Pharmacology, APHP, Saint-Antoine hospital, Paris 6 University, Paris, Department of Gynaecology, APHP, Saint-Antoine hospital, Paris, Clinical Investigation Center, CHU, Nancy, Clinical Investigation Center, CHU, Brest, Clinical Investigation Center, Department of Clinical Pharmacology, AP-HP Saint-Antoine hospital, Paris 6 University, Paris, France Introduction: Increased risk of venous thrombosis during oral hormone therapy in postmenopausal women is related to estrogen-induced hypercoagulable state. Lower estrogen dose is recommended, but the effect of hormone dose optimisation on haemostasis has not been studied. Aim of the study: To evaluate the influence of two different doses of daily oral 17beta-estradiol therapy compared with placebo, on thrombin generation (TG) in healthy postmenopausal women. Materials-Methods: Seventy two menopausal women were randomized to receive daily 1mg (n =24) or 2mg (n =26) of 17beta-estradiol associated with 10mg dydrogesterone or placebo (n =22). TG was monitored before and 2 months after treatment using the Calibrated Automated Thrombogram® (Stago, France). Results: At baseline parameters of TG were not statistically different in the three study groups. Two months after randomisation, lag time and time to reach the peak of thrombin were decreased while the mean rate index and the peak of thrombin were significantly increased in the two groups of hormone-treated women as compared to placebo group. Endogenous thrombin potential remained unchanged. No difference was observed in TG parameters between women receiving lower and higher dose of 17betaestradiol. Conclusions: Oral hormone therapy with 2mg of 17beta-estradiol for two months induced acceleration and increase of TG. Lowering the dose by 1mg did not attenuate this effect. On the contrary endogenous thrombin potential was not influenced in any dose. The clinical significance of the profile of TG of postmenopausal women being on hormone therapy remains to be explored. Table 1: Parameters of thrombin generation 2 months after randomisation (Treatment with two different doses of 17beta-estradiol associated with dydrogesterone or placebo) placebo 17beta-estradiol" @default.
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• W2126834460 date "2011-02-01" @default.
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• W2126834460 title "O.04b Effect of the dose of oral treatment with 17beta-estradiol associated with dydrogesterone on thrombin generation in healthy postmenopausal women: a randomized double-blind placebo-controlled study" @default.
• W2126834460 doi "https://doi.org/10.1016/s0049-3848(11)70040-8" @default.
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