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- W2126844124 endingPage "BMI.S630" @default.
- W2126844124 startingPage "BMI.S630" @default.
- W2126844124 abstract "Crohn's disease and ulcerative colitis are inflammatory bowel diseases (IBD) quite common in the United States and other Western countries. Patients suffering IBD are at greater risk of developing colorectal adenocarcinoma than the general population. Both, the adenoma-carcinoma and the inflammation-carcinogenesis processes are characterized by active angiogenesis. Recent studies also have shown that anti-angiogenesis might be a novel therapeutic approach for IBD. Thrombospondin 1 (TSP1) is an extracellular protein well known for its anti-angiogenic properties. TSP1 also has key functions in inflammation, which is assumed to be the primary cause for carcinogenesis in IBD. This review is focused on the role of TSP1 in colorectal carcinogenesis. The therapeutic effects of TSP derived-peptides on inhibiting the inflammation-carcinogenesis progression are also discussed." @default.
- W2126844124 created "2016-06-24" @default.
- W2126844124 creator A5033400358 @default.
- W2126844124 date "2008-01-01" @default.
- W2126844124 modified "2023-09-24" @default.
- W2126844124 title "The Role of Thrombospondin 1 on Intestinal Inflammation and Carcinogenesis" @default.
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- W2126844124 doi "https://doi.org/10.4137/bmi.s630" @default.
- W2126844124 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2600574" @default.
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