FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2126873637> ?p ?o ?g. }

• W2126873637 endingPage "17641" @default.
• W2126873637 startingPage "17636" @default.
• W2126873637 abstract "The phosphorylation state of the C-terminal repeat domain (CTD) of the largest subunit of RNA polymerase II changes as polymerase transcribes a gene, and the distinct forms of the phospho-CTD (PCTD) recruit different nuclear factors to elongating polymerase. The Set2 histone methyltransferase from yeast was recently shown to bind the PCTD of elongating RNA polymerase II by means of a novel domain termed the Set2-Rpb1 interacting (SRI) domain. Here, we report the solution structure of the SRI domain in human Set2 (hSRI domain), which adopts a left-turned three-helix bundle distinctly different from other structurally characterized PCTD-interacting domains. NMR titration experiments mapped the binding surface of the hSRI domain to helices 1 and 2, and Biacore binding studies showed that the domain binds preferably to [Ser-2 + Ser-5]-phosphorylated CTD peptides containing two or more heptad repeats. Point-mutagenesis studies identified five residues critical for PCTD binding. In view of the differential effects of these point mutations on binding to different CTD phosphopeptides, we propose a model for the hSRI domain interaction with the PCTD." @default.
• W2126873637 created "2016-06-24" @default.
• W2126873637 creator A5003416661 @default.
• W2126873637 creator A5021384155 @default.
• W2126873637 creator A5021631597 @default.
• W2126873637 creator A5045805144 @default.
• W2126873637 creator A5054455401 @default.
• W2126873637 creator A5091566121 @default.
• W2126873637 date "2005-11-28" @default.
• W2126873637 modified "2023-09-26" @default.
• W2126873637 title "Solution structure of the Set2–Rpb1 interacting domain of human Set2 and its interaction with the hyperphosphorylated C-terminal domain of Rpb1" @default.
• W2126873637 cites W1496804377 @default.
• W2126873637 cites W1963600172 @default.
• W2126873637 cites W1978314322 @default.
• W2126873637 cites W1988904557 @default.
• W2126873637 cites W1993807753 @default.
• W2126873637 cites W2000948557 @default.
• W2126873637 cites W2002195659 @default.
• W2126873637 cites W2012287373 @default.
• W2126873637 cites W2013286714 @default.
• W2126873637 cites W2022936085 @default.
• W2126873637 cites W2031390327 @default.
• W2126873637 cites W2041372179 @default.
• W2126873637 cites W2072836045 @default.
• W2126873637 cites W2074661080 @default.
• W2126873637 cites W2079652085 @default.
• W2126873637 cites W2085835009 @default.
• W2126873637 cites W2089958448 @default.
• W2126873637 cites W2093290846 @default.
• W2126873637 cites W2101656044 @default.
• W2126873637 cites W2110180722 @default.
• W2126873637 cites W2116887390 @default.
• W2126873637 cites W2140448223 @default.
• W2126873637 cites W2155820845 @default.
• W2126873637 cites W2160720092 @default.
• W2126873637 cites W2162125140 @default.
• W2126873637 cites W2163721363 @default.
• W2126873637 cites W2164259744 @default.
• W2126873637 cites W2166944279 @default.
• W2126873637 cites W2168696636 @default.
• W2126873637 cites W2168802470 @default.
• W2126873637 cites W2169821755 @default.
• W2126873637 cites W2170671445 @default.
• W2126873637 cites W2170728895 @default.
• W2126873637 cites W2171119496 @default.
• W2126873637 cites W2409365873 @default.
• W2126873637 doi "https://doi.org/10.1073/pnas.0506350102" @default.
• W2126873637 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1308900" @default.
• W2126873637 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16314571" @default.
• W2126873637 hasPublicationYear "2005" @default.
• W2126873637 type Work @default.
• W2126873637 sameAs 2126873637 @default.
• W2126873637 citedByCount "120" @default.
• W2126873637 countsByYear W21268736372012 @default.
• W2126873637 countsByYear W21268736372013 @default.
• W2126873637 countsByYear W21268736372014 @default.
• W2126873637 countsByYear W21268736372015 @default.
• W2126873637 countsByYear W21268736372016 @default.
• W2126873637 countsByYear W21268736372017 @default.
• W2126873637 countsByYear W21268736372018 @default.
• W2126873637 countsByYear W21268736372019 @default.
• W2126873637 countsByYear W21268736372020 @default.
• W2126873637 countsByYear W21268736372021 @default.
• W2126873637 countsByYear W21268736372022 @default.
• W2126873637 countsByYear W21268736372023 @default.
• W2126873637 crossrefType "journal-article" @default.
• W2126873637 hasAuthorship W2126873637A5003416661 @default.
• W2126873637 hasAuthorship W2126873637A5021384155 @default.
• W2126873637 hasAuthorship W2126873637A5021631597 @default.
• W2126873637 hasAuthorship W2126873637A5045805144 @default.
• W2126873637 hasAuthorship W2126873637A5054455401 @default.
• W2126873637 hasAuthorship W2126873637A5091566121 @default.
• W2126873637 hasBestOaLocation W21268736372 @default.
• W2126873637 hasConcept C101762097 @default.
• W2126873637 hasConcept C104317684 @default.
• W2126873637 hasConcept C107824862 @default.
• W2126873637 hasConcept C111368507 @default.
• W2126873637 hasConcept C125533998 @default.
• W2126873637 hasConcept C12554922 @default.
• W2126873637 hasConcept C127313418 @default.
• W2126873637 hasConcept C150194340 @default.
• W2126873637 hasConcept C153911025 @default.
• W2126873637 hasConcept C156569929 @default.
• W2126873637 hasConcept C185592680 @default.
• W2126873637 hasConcept C25166345 @default.
• W2126873637 hasConcept C515207424 @default.
• W2126873637 hasConcept C55493867 @default.
• W2126873637 hasConcept C57711820 @default.
• W2126873637 hasConcept C64350747 @default.
• W2126873637 hasConcept C86339819 @default.
• W2126873637 hasConcept C86803240 @default.
• W2126873637 hasConcept C94966510 @default.
• W2126873637 hasConcept C95444343 @default.
• W2126873637 hasConceptScore W2126873637C101762097 @default.
• W2126873637 hasConceptScore W2126873637C104317684 @default.
• W2126873637 hasConceptScore W2126873637C107824862 @default.
• W2126873637 hasConceptScore W2126873637C111368507 @default.
• W2126873637 hasConceptScore W2126873637C125533998 @default.

• next