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• W2126889841 abstract "Transcriptional activation of the cyclin D1 gene (CCND1) plays a pivotal role in G1-phase progression, which is thereby controlled by multiple regulatory factors, including nuclear receptors (NRs). Appropriate CCND1 gene activity is essential for normal development and physiology of the mammary gland, where it is regulated by ovarian steroids through a mechanism(s) that is not fully elucidated. We report here that CCND1 promoter activation by estrogens in human breast cancer cells is mediated by recruitment of a c-Jun/c-Fos/estrogen receptor α complex to the tetradecanoyl phorbol acetate-responsive element of the gene, together with Oct-1 to a site immediately adjacent. This process coincides with the release from the same DNA region of a transcriptional repressor complex including Yin-Yang 1 (YY1) and histone deacetylase 1 and is sufficient to induce the assembly of the basal transcription machinery on the promoter and to lead to initial cyclin D1 accumulation in the cell. Later on in estrogen stimulation, the cyclin D1/Cdk4 holoenzyme associates with the CCND1 promoter, where E2F and pRb can also be found, contributing to the long-lasting gene enhancement required to drive G1-phase completion. Interestingly, progesterone triggers similar regulatory events through its own NRs, suggesting that the gene regulation cascade described here represents a crossroad for the transcriptional control of G1-phase progression by different classes of NRs." @default.
• W2126889841 created "2016-06-24" @default.
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• W2126889841 date "2004-08-01" @default.
• W2126889841 modified "2023-10-16" @default.
• W2126889841 title "Estrogens and Progesterone Promote Persistent <i>CCND1</i> Gene Activation during G₁ by Inducing Transcriptional Derepression via c-<i>Jun</i>/c-<i>Fos</i>/Estrogen Receptor (Progesterone Receptor) Complex Assembly to a Distal Regulatory Element and Recruitment of Cyclin D1 to Its Own Gene Promoter" @default.
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• W2126889841 doi "https://doi.org/10.1128/mcb.24.16.7260-7274.2004" @default.
• W2126889841 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/479712" @default.
• W2126889841 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15282324" @default.
• W2126889841 hasPublicationYear "2004" @default.
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