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- W2126935349 abstract "The effect of nitrendipine on the cardiovascular responses to tracheal intubation was studied in a placebocontrolled, randomised, double–blind trial. Thirty patients (ASA physical status 1) undergoing elective surgery either 5 or 10 mg nitrendipine, or a placebo orally 3 h before induction of anaesthesia (n = 10 for each group). Anaesthesia was induced with sodium thiopentone 5 mg/kg i.v. and tracheal intubation was facilitated with vecuronium 0.2 mg/kg i.v. Patients receiving the placebo showed a significant increase in the mean arterial pressure and the rate–pressure product in response to tracheal intubation. These increases following intubation were reduced in nitrendipine–treated patients compared with the placebo group (P < 0.05). Oral administration of nitrendipine (5 or 10 mg, 3 h before induction of anaesthesia) was able to attenuate the hypertensive response to tracheal intubation in ASA 1 patients under light anaesthesia. We propose this pharmacological technique with supplementary doses of opioids and/or benzodiazepines for the management of patients with hypertension or coronary artery disease." @default.
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- W2126935349 date "1993-10-01" @default.
- W2126935349 modified "2023-09-27" @default.
- W2126935349 title "Attenuation of the pressor response to tracheal intubation with oral nitrendipine" @default.
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- W2126935349 doi "https://doi.org/10.1111/j.1399-6576.1993.tb03786.x" @default.
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