FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2126939696> ?p ?o ?g. }

• W2126939696 endingPage "1385" @default.
• W2126939696 startingPage "1377" @default.
• W2126939696 abstract "Bombesin-like peptides promote fetal lung development. Normally, levels of mammalian bombesin (gastrin-releasing peptide [GRP]) drop postnatally, but these levels are elevated in newborns that develop bronchopulmonary dysplasia (BPD), a chronic lung disease characterized by arrested alveolarization. In premature baboons with BPD, antibombesin antibodies reduce lung injury and promote alveolarization.The present study tests whether exogenous bombesin or GRP given perinatally alters alveolar development in newborn mice.Mice were given peptides intraperitoneally twice daily on Postnatal Days 1-3. On Day 14 lungs were inflation-fixed for histopathologic analyses of alveolarization.Bombesin had multiple effects on Day 14 lung, when alveolarization was about half complete. First, bombesin induced alveolar myofibroblast proliferation and increased alveolar wall thickness compared with saline-treated control animals. Second, bombesin diminished alveolarization in C57BL/6 (but not Swiss-Webster) mice. We used receptor-null mice to explore which receptors might mediate these effects. Compared with wild-type littermates, bombesin-treated GRP receptor (GRPR)-null mice had increased interstitial fibrosis but reduced defects in alveolarization. Neuromedin B (NMB) receptor-null and bombesin receptor subtype 3-null mice had the same responses as their wild-type littermates. GRP had the same effects as bombesin, whereas neither NMB nor a synthetic bombesin receptor type 3 ligand had any effect. All effects of GRP were abrogated in GRPR-null mice.Bombesin/GRP can induce features of BPD, including interstitial fibrosis and diminished alveolarization. GRPR appears to mediate all effects of GRP, but only part of the bombesin effect on alveolarization, suggesting that novel receptors may mediate some effects of bombesin in newborn lung." @default.
• W2126939696 created "2016-06-24" @default.
• W2126939696 creator A5014557833 @default.
• W2126939696 creator A5015379721 @default.
• W2126939696 creator A5033376623 @default.
• W2126939696 creator A5059410994 @default.
• W2126939696 creator A5066839782 @default.
• W2126939696 creator A5069355953 @default.
• W2126939696 creator A5087496453 @default.
• W2126939696 date "2006-06-15" @default.
• W2126939696 modified "2023-10-16" @default.
• W2126939696 title "Bombesin Inhibits Alveolarization and Promotes Pulmonary Fibrosis in Newborn Mice" @default.
• W2126939696 cites W1545856647 @default.
• W2126939696 cites W1573917099 @default.
• W2126939696 cites W1735099752 @default.
• W2126939696 cites W1863824423 @default.
• W2126939696 cites W1915110884 @default.
• W2126939696 cites W1967959580 @default.
• W2126939696 cites W1968809092 @default.
• W2126939696 cites W1989861100 @default.
• W2126939696 cites W2005017658 @default.
• W2126939696 cites W2005688520 @default.
• W2126939696 cites W2011072758 @default.
• W2126939696 cites W2012645617 @default.
• W2126939696 cites W2013363497 @default.
• W2126939696 cites W2029529938 @default.
• W2126939696 cites W2038066314 @default.
• W2126939696 cites W2039691435 @default.
• W2126939696 cites W2056454020 @default.
• W2126939696 cites W2057830281 @default.
• W2126939696 cites W2062098928 @default.
• W2126939696 cites W2063586298 @default.
• W2126939696 cites W2072064360 @default.
• W2126939696 cites W2073771842 @default.
• W2126939696 cites W2076616785 @default.
• W2126939696 cites W2077474535 @default.
• W2126939696 cites W2078470769 @default.
• W2126939696 cites W2078535400 @default.
• W2126939696 cites W2079140686 @default.
• W2126939696 cites W2090651489 @default.
• W2126939696 cites W2093831382 @default.
• W2126939696 cites W2118175636 @default.
• W2126939696 cites W2135965744 @default.
• W2126939696 cites W2139582491 @default.
• W2126939696 cites W2149069360 @default.
• W2126939696 cites W2163147211 @default.
• W2126939696 cites W2303487642 @default.
• W2126939696 cites W2412932947 @default.
• W2126939696 cites W4256646524 @default.
• W2126939696 cites W88057853 @default.
• W2126939696 doi "https://doi.org/10.1164/rccm.200507-1014oc" @default.
• W2126939696 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2662976" @default.
• W2126939696 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16603607" @default.
• W2126939696 hasPublicationYear "2006" @default.
• W2126939696 type Work @default.
• W2126939696 sameAs 2126939696 @default.
• W2126939696 citedByCount "48" @default.
• W2126939696 countsByYear W21269396962012 @default.
• W2126939696 countsByYear W21269396962013 @default.
• W2126939696 countsByYear W21269396962014 @default.
• W2126939696 countsByYear W21269396962015 @default.
• W2126939696 countsByYear W21269396962017 @default.
• W2126939696 countsByYear W21269396962018 @default.
• W2126939696 countsByYear W21269396962020 @default.
• W2126939696 countsByYear W21269396962021 @default.
• W2126939696 countsByYear W21269396962022 @default.
• W2126939696 crossrefType "journal-article" @default.
• W2126939696 hasAuthorship W2126939696A5014557833 @default.
• W2126939696 hasAuthorship W2126939696A5015379721 @default.
• W2126939696 hasAuthorship W2126939696A5033376623 @default.
• W2126939696 hasAuthorship W2126939696A5059410994 @default.
• W2126939696 hasAuthorship W2126939696A5066839782 @default.
• W2126939696 hasAuthorship W2126939696A5069355953 @default.
• W2126939696 hasAuthorship W2126939696A5087496453 @default.
• W2126939696 hasBestOaLocation W21269396962 @default.
• W2126939696 hasConcept C118303440 @default.
• W2126939696 hasConcept C126322002 @default.
• W2126939696 hasConcept C134018914 @default.
• W2126939696 hasConcept C170493617 @default.
• W2126939696 hasConcept C2776998989 @default.
• W2126939696 hasConcept C2777714996 @default.
• W2126939696 hasConcept C2778448772 @default.
• W2126939696 hasConcept C2780559512 @default.
• W2126939696 hasConcept C2781244666 @default.
• W2126939696 hasConcept C71924100 @default.
• W2126939696 hasConceptScore W2126939696C118303440 @default.
• W2126939696 hasConceptScore W2126939696C126322002 @default.
• W2126939696 hasConceptScore W2126939696C134018914 @default.
• W2126939696 hasConceptScore W2126939696C170493617 @default.
• W2126939696 hasConceptScore W2126939696C2776998989 @default.
• W2126939696 hasConceptScore W2126939696C2777714996 @default.
• W2126939696 hasConceptScore W2126939696C2778448772 @default.
• W2126939696 hasConceptScore W2126939696C2780559512 @default.
• W2126939696 hasConceptScore W2126939696C2781244666 @default.
• W2126939696 hasConceptScore W2126939696C71924100 @default.
• W2126939696 hasIssue "12" @default.
• W2126939696 hasLocation W21269396961 @default.
• W2126939696 hasLocation W21269396962 @default.

• next