FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2126943932> ?p ?o ?g. }

• W2126943932 endingPage "672" @default.
• W2126943932 startingPage "664" @default.
• W2126943932 abstract "It has been shown that the transcription factor NF-kappaB is necessary for late phase cardioprotection after ischemic preconditioning (IPC) in the heart, and yet is injurious after ischemia/reperfusion (I/R). However the downstream gene expression programs that underlie the contribution of NF-kappaB to cardioprotection after late IPC are incompletely understood. The objective of this study was to delineate the specific genes that are regulated by NF-kappaB immediately after a late IPC stimulus and validate the methodology for the identification of NF-kappaB-dependent genes that contribute to cardioprotection. A directed microarray analysis identified 238 genes as up or downregulated in an NF-kappaB-dependent manner 3.5h after late IPC. Among these are several genes previously implicated in late IPC. Gene ontological analysis showed that the most significant group of NF-kappaB-dependent genes are heat shock response genes, including the genes encoding Hsp70.1 and Hsp70.3. Though an Hsp70.1/70.3 double knockout failed to exhibit cardioprotection, late IPC was intact in the Hsp70.1 single knockout. After I/R, the Hsp70.1/70.3 double knockout and the Hsp70.1 single knockout had significantly increased and reduced infarct size, respectively. These results delineate the immediate NF-kappaB-dependent transcriptome after late IPC. One of the major categories of NF-kappaB-dependent genes induced by late IPC is the heat shock response. The results of infarct studies confirm that Hsp70.3 is protective after IPC. However, though Hsp70.1 and Hsp70.3 are coordinately regulated, their functions are opposing after I/R injury." @default.
• W2126943932 created "2016-06-24" @default.
• W2126943932 creator A5002769070 @default.
• W2126943932 creator A5026433129 @default.
• W2126943932 creator A5028712728 @default.
• W2126943932 creator A5031989527 @default.
• W2126943932 creator A5043501456 @default.
• W2126943932 creator A5054509601 @default.
• W2126943932 creator A5056242959 @default.
• W2126943932 creator A5057856712 @default.
• W2126943932 date "2010-10-01" @default.
• W2126943932 modified "2023-10-17" @default.
• W2126943932 title "NF-κB driven cardioprotective gene programs; Hsp70.3 and cardioprotection after late ischemic preconditioning" @default.
• W2126943932 cites W1564388687 @default.
• W2126943932 cites W1570746489 @default.
• W2126943932 cites W1974898522 @default.
• W2126943932 cites W1979446481 @default.
• W2126943932 cites W198510997 @default.
• W2126943932 cites W1991117742 @default.
• W2126943932 cites W1993031309 @default.
• W2126943932 cites W2002008095 @default.
• W2126943932 cites W2002708977 @default.
• W2126943932 cites W2016983085 @default.
• W2126943932 cites W2018802599 @default.
• W2126943932 cites W2024843544 @default.
• W2126943932 cites W2025899545 @default.
• W2126943932 cites W2034978492 @default.
• W2126943932 cites W2040794497 @default.
• W2126943932 cites W2044201576 @default.
• W2126943932 cites W2045439658 @default.
• W2126943932 cites W2046429224 @default.
• W2126943932 cites W2048543877 @default.
• W2126943932 cites W2053472971 @default.
• W2126943932 cites W2069075668 @default.
• W2126943932 cites W2075208875 @default.
• W2126943932 cites W2080605373 @default.
• W2126943932 cites W2081098333 @default.
• W2126943932 cites W2081155723 @default.
• W2126943932 cites W2082001748 @default.
• W2126943932 cites W2087160727 @default.
• W2126943932 cites W2093377325 @default.
• W2126943932 cites W2098659547 @default.
• W2126943932 cites W2099388441 @default.
• W2126943932 cites W2106925175 @default.
• W2126943932 cites W2107277218 @default.
• W2126943932 cites W2107544067 @default.
• W2126943932 cites W2109936231 @default.
• W2126943932 cites W2110204147 @default.
• W2126943932 cites W2111909824 @default.
• W2126943932 cites W2113620806 @default.
• W2126943932 cites W2121777852 @default.
• W2126943932 cites W2122683221 @default.
• W2126943932 cites W2128565840 @default.
• W2126943932 cites W2129932871 @default.
• W2126943932 cites W2130065841 @default.
• W2126943932 cites W2131778751 @default.
• W2126943932 cites W2132494613 @default.
• W2126943932 cites W2136273830 @default.
• W2126943932 cites W2140735579 @default.
• W2126943932 cites W2140797773 @default.
• W2126943932 cites W2146217294 @default.
• W2126943932 cites W2148658873 @default.
• W2126943932 cites W2152886450 @default.
• W2126943932 cites W2158217645 @default.
• W2126943932 cites W2160696128 @default.
• W2126943932 cites W2165523086 @default.
• W2126943932 cites W2166440547 @default.
• W2126943932 cites W2170116177 @default.
• W2126943932 cites W2170945707 @default.
• W2126943932 cites W2209282997 @default.
• W2126943932 cites W238668910 @default.
• W2126943932 doi "https://doi.org/10.1016/j.yjmcc.2010.07.001" @default.
• W2126943932 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3570030" @default.
• W2126943932 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20643136" @default.
• W2126943932 hasPublicationYear "2010" @default.
• W2126943932 type Work @default.
• W2126943932 sameAs 2126943932 @default.
• W2126943932 citedByCount "42" @default.
• W2126943932 countsByYear W21269439322012 @default.
• W2126943932 countsByYear W21269439322013 @default.
• W2126943932 countsByYear W21269439322014 @default.
• W2126943932 countsByYear W21269439322015 @default.
• W2126943932 countsByYear W21269439322016 @default.
• W2126943932 countsByYear W21269439322017 @default.
• W2126943932 countsByYear W21269439322018 @default.
• W2126943932 countsByYear W21269439322019 @default.
• W2126943932 countsByYear W21269439322020 @default.
• W2126943932 countsByYear W21269439322021 @default.
• W2126943932 countsByYear W21269439322022 @default.
• W2126943932 countsByYear W21269439322023 @default.
• W2126943932 crossrefType "journal-article" @default.
• W2126943932 hasAuthorship W2126943932A5002769070 @default.
• W2126943932 hasAuthorship W2126943932A5026433129 @default.
• W2126943932 hasAuthorship W2126943932A5028712728 @default.
• W2126943932 hasAuthorship W2126943932A5031989527 @default.
• W2126943932 hasAuthorship W2126943932A5043501456 @default.
• W2126943932 hasAuthorship W2126943932A5054509601 @default.
• W2126943932 hasAuthorship W2126943932A5056242959 @default.

• next