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• W2126945155 abstract "A rapid lateral flow immunoassay (LFIA) (STic Expert(®) HIT), recently developed for the diagnosis of heparin-induced thrombocytopenia (HIT), was evaluated in a prospective multicentre cohort of 334 consecutive patients. The risk of HIT was estimated by the 4Ts score as low, intermediate and high in 28·7%, 61·7% and 9·6% of patients, respectively. Definite HIT was diagnosed in 40 patients (12·0%) with positive results on both enzyme-linked immunosorbent assay (Asserachrom(®) HPIA IgG) and serotonin release assay. The inter-reader reproducibility of results obtained was excellent (kappa ratio > 0·9). The negative predictive value of LFIA with plasma samples was 99·6% with a negative likelihood ratio (LR) of 0·03, and was comparable to those of the particle gel immunoassay (H/PF4-PaGIA(®) ) performed in 124 cases. Positive predictive value and positive LR were 44·4% and 5·87, respectively, and the results were similar for serum samples. The probability of HIT in intermediate risk patients decreased from 11·2% to 0·4% when the LFIA result was negative and increased to 42·5% when it was positive. In conclusion, the STic Expert(®) HIT combined with the 4Ts score is a reliable tool to rule out the diagnosis of HIT." @default.
• W2126945155 created "2016-06-24" @default.
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• W2126945155 date "2014-05-12" @default.
• W2126945155 modified "2023-10-13" @default.
• W2126945155 title "Prospective evaluation of a rapid nanoparticle-based lateral flow immunoassay (STic Expert^®HIT) for the diagnosis of heparin-induced thrombocytopenia" @default.
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• W2126945155 doi "https://doi.org/10.1111/bjh.12939" @default.
• W2126945155 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24815503" @default.
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