FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2126948051> ?p ?o ?g. }

• W2126948051 endingPage "209" @default.
• W2126948051 startingPage "196" @default.
• W2126948051 abstract "Methotrexate (MTX) is used for rheumatoid arthritis (RA) treatment showing a wide toxicity profile. This study aimed to evaluate the influence of single nucleotide polymorphisms (SNPs) in genes encoding for MTX transporters with the occurrence of MTX-related toxicity (overall and gastrointestinal). A total of 233 Portuguese RA patients were genotyped for 23 SNPs. Haplotype analyses were performed and a toxicogenetic risk index (TRI) was created for SNPs that revealed to be statistically significant. Regarding MTX overall toxicity, an increased risk was associated to SLC19A1 rs7499 G carriers (p = 0.017), SLC46A1 rs2239907 GG (p = 0.030) and, SLCO1B1 rs4149056 T carriers (p = 0.040) and TT (p = 0.019). TRI revealed that patients with Index 3 were 18-fold more likely to present an adverse drug reaction when compared to those with Index 1 (p = 0.001). For MTX gastrointestinal toxicity, results demonstrated an increased risk associated with SLC19A1 rs7499 G carriers (p = 0.012) and GG (p = 0.045), SLC19A1 rs1051266 G carriers (p = 0.034), SLC19A1 rs2838956 A carriers (p = 0.049) and, SLCO1B1 rs4149056 T carriers (p = 0.042) and TT (p = 0.025). Haplotype analyses showed association between GGAG haplotype for SLC19A1 rs7499, rs1051266, rs2838956 and rs3788200 with MTX gastrointestinal toxicity (p = 0.029). TRI revealed that patients with Index 4 were 9-fold more likely to present a gastrointestinal disorder when compared to those with Index 1 (p = 0.020). This study demonstrated that SLC19A1, SLC46A1 and SLCO1B1 genotypes may help to identify patients with increased risk of MTX-related overall toxicity and that SLC19A1 and SLCO1B1 genotypes, and SLC19A1 haplotypes may help to identify patients with increased risk of MTX-related gastrointestinal toxicity." @default.
• W2126948051 created "2016-06-24" @default.
• W2126948051 creator A5002735203 @default.
• W2126948051 creator A5008746670 @default.
• W2126948051 creator A5029273559 @default.
• W2126948051 creator A5045584014 @default.
• W2126948051 creator A5079813962 @default.
• W2126948051 creator A5087982690 @default.
• W2126948051 creator A5088828076 @default.
• W2126948051 date "2014-08-14" @default.
• W2126948051 modified "2023-09-25" @default.
• W2126948051 title "SLC19A1, SLC46A1 and SLCO1B1 Polymorphisms as Predictors of Methotrexate-Related Toxicity in Portuguese Rheumatoid Arthritis Patients" @default.
• W2126948051 cites W1581725900 @default.
• W2126948051 cites W1788032165 @default.
• W2126948051 cites W1965049677 @default.
• W2126948051 cites W1966883331 @default.
• W2126948051 cites W1969552935 @default.
• W2126948051 cites W1973381541 @default.
• W2126948051 cites W1974737003 @default.
• W2126948051 cites W1986348861 @default.
• W2126948051 cites W1995019701 @default.
• W2126948051 cites W2011669229 @default.
• W2126948051 cites W2027504487 @default.
• W2126948051 cites W2027786827 @default.
• W2126948051 cites W2028420840 @default.
• W2126948051 cites W2034032932 @default.
• W2126948051 cites W2037359949 @default.
• W2126948051 cites W2038526706 @default.
• W2126948051 cites W2042604481 @default.
• W2126948051 cites W2049899981 @default.
• W2126948051 cites W2051185856 @default.
• W2126948051 cites W2058859643 @default.
• W2126948051 cites W2064037617 @default.
• W2126948051 cites W2065293032 @default.
• W2126948051 cites W2076194172 @default.
• W2126948051 cites W2078993588 @default.
• W2126948051 cites W2079197876 @default.
• W2126948051 cites W2081407149 @default.
• W2126948051 cites W2090430326 @default.
• W2126948051 cites W2098824600 @default.
• W2126948051 cites W2104669609 @default.
• W2126948051 cites W2105393789 @default.
• W2126948051 cites W2110177517 @default.
• W2126948051 cites W2111335833 @default.
• W2126948051 cites W2117867091 @default.
• W2126948051 cites W2119226590 @default.
• W2126948051 cites W2130422352 @default.
• W2126948051 cites W2131297071 @default.
• W2126948051 cites W2137780659 @default.
• W2126948051 cites W2150772680 @default.
• W2126948051 cites W2154362046 @default.
• W2126948051 cites W2160859576 @default.
• W2126948051 cites W2161955595 @default.
• W2126948051 cites W2166174569 @default.
• W2126948051 cites W2413905319 @default.
• W2126948051 doi "https://doi.org/10.1093/toxsci/kfu162" @default.
• W2126948051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25124723" @default.
• W2126948051 hasPublicationYear "2014" @default.
• W2126948051 type Work @default.
• W2126948051 sameAs 2126948051 @default.
• W2126948051 citedByCount "51" @default.
• W2126948051 countsByYear W21269480512015 @default.
• W2126948051 countsByYear W21269480512016 @default.
• W2126948051 countsByYear W21269480512017 @default.
• W2126948051 countsByYear W21269480512018 @default.
• W2126948051 countsByYear W21269480512019 @default.
• W2126948051 countsByYear W21269480512020 @default.
• W2126948051 countsByYear W21269480512021 @default.
• W2126948051 countsByYear W21269480512022 @default.
• W2126948051 countsByYear W21269480512023 @default.
• W2126948051 crossrefType "journal-article" @default.
• W2126948051 hasAuthorship W2126948051A5002735203 @default.
• W2126948051 hasAuthorship W2126948051A5008746670 @default.
• W2126948051 hasAuthorship W2126948051A5029273559 @default.
• W2126948051 hasAuthorship W2126948051A5045584014 @default.
• W2126948051 hasAuthorship W2126948051A5079813962 @default.
• W2126948051 hasAuthorship W2126948051A5087982690 @default.
• W2126948051 hasAuthorship W2126948051A5088828076 @default.
• W2126948051 hasBestOaLocation W21269480511 @default.
• W2126948051 hasConcept C104317684 @default.
• W2126948051 hasConcept C126322002 @default.
• W2126948051 hasConcept C135763542 @default.
• W2126948051 hasConcept C153209595 @default.
• W2126948051 hasConcept C197754878 @default.
• W2126948051 hasConcept C2776598434 @default.
• W2126948051 hasConcept C2777575956 @default.
• W2126948051 hasConcept C2781059491 @default.
• W2126948051 hasConcept C29730261 @default.
• W2126948051 hasConcept C54355233 @default.
• W2126948051 hasConcept C71924100 @default.
• W2126948051 hasConcept C86803240 @default.
• W2126948051 hasConcept C90924648 @default.
• W2126948051 hasConcept C98274493 @default.
• W2126948051 hasConceptScore W2126948051C104317684 @default.
• W2126948051 hasConceptScore W2126948051C126322002 @default.
• W2126948051 hasConceptScore W2126948051C135763542 @default.
• W2126948051 hasConceptScore W2126948051C153209595 @default.
• W2126948051 hasConceptScore W2126948051C197754878 @default.

• next