FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2126959065> ?p ?o ?g. }

• W2126959065 endingPage "125" @default.
• W2126959065 startingPage "119" @default.
• W2126959065 abstract "Mitochondria have been associated with aging in many experimental systems through the damaging action of reactive oxygen species. There is more, however, to the connection between mitochondria and Saccharomyces cerevisiae longevity and aging. Induction of the retrograde response, a pathway signaling mitochondrial dysfunction, results in the extension of life span and postponement of the manifestations of aging, changing the metabolic and stress resistance status of the cell. A paradox associated with the retrograde response is the simultaneous triggering of extrachromosomal ribosomal DNA circle (ERC) production, because of the deleterious effect these circles have on yeast longevity. The retrograde response gene RTG2 appears to play a pivotal role in ERC production, linking metabolism and genome stability. In addition to mother cell aging, mitochondria are important in establishment of age asymmetry between mother and daughter cells. The results more generally point to the existence of a mechanism to filter damaged components from daughter cells, a form of checkpoint control. Mitochondrial integrity is affected by the PHB1 and PHB2 genes, which encode inner mitochondrial membrane chaperones called prohibitins. The Phb1/2 proteins protect the cell from imbalances in the production of mitochondrial proteins. Such imbalances appear to cause a stochastic stratification of the yeast population with the appearance of short-lived cells. Ras2p impacts this process. Maintenance of mitochondrial membrane potential and the provision of Krebs cycle intermediates for biosyntheses appear to be crucial elements in yeast longevity. In sum, it is clear that mitochondria lie at the nexus of yeast longevity and aging." @default.
• W2126959065 created "2016-06-24" @default.
• W2126959065 creator A5025480370 @default.
• W2126959065 date "2004-11-01" @default.
• W2126959065 modified "2023-10-09" @default.
• W2126959065 title "Yeast replicative life span – the mitochondrial connection" @default.
• W2126959065 cites W1493802244 @default.
• W2126959065 cites W1522402713 @default.
• W2126959065 cites W1879890282 @default.
• W2126959065 cites W1963578989 @default.
• W2126959065 cites W1964140976 @default.
• W2126959065 cites W1992663222 @default.
• W2126959065 cites W1995494753 @default.
• W2126959065 cites W2005919395 @default.
• W2126959065 cites W2010292457 @default.
• W2126959065 cites W2011094024 @default.
• W2126959065 cites W2019139535 @default.
• W2126959065 cites W2025873104 @default.
• W2126959065 cites W2030792701 @default.
• W2126959065 cites W2035506644 @default.
• W2126959065 cites W2047945565 @default.
• W2126959065 cites W2048967691 @default.
• W2126959065 cites W2052661082 @default.
• W2126959065 cites W2057162313 @default.
• W2126959065 cites W2060036179 @default.
• W2126959065 cites W2067395327 @default.
• W2126959065 cites W2067820742 @default.
• W2126959065 cites W2071816222 @default.
• W2126959065 cites W2082918093 @default.
• W2126959065 cites W2090095688 @default.
• W2126959065 cites W2092587339 @default.
• W2126959065 cites W2098385754 @default.
• W2126959065 cites W2098553470 @default.
• W2126959065 cites W2102361004 @default.
• W2126959065 cites W2110435452 @default.
• W2126959065 cites W2111882191 @default.
• W2126959065 cites W2114721511 @default.
• W2126959065 cites W2115299520 @default.
• W2126959065 cites W2119090089 @default.
• W2126959065 cites W2128387695 @default.
• W2126959065 cites W2128784816 @default.
• W2126959065 cites W2130859321 @default.
• W2126959065 cites W2132015995 @default.
• W2126959065 cites W2132147485 @default.
• W2126959065 cites W2155265427 @default.
• W2126959065 cites W2156979038 @default.
• W2126959065 cites W2168453023 @default.
• W2126959065 cites W2168634908 @default.
• W2126959065 cites W2169423549 @default.
• W2126959065 cites W2171991500 @default.
• W2126959065 cites W2200736706 @default.
• W2126959065 cites W2326129438 @default.
• W2126959065 cites W261942502 @default.
• W2126959065 cites W3021964391 @default.
• W2126959065 cites W62615095 @default.
• W2126959065 doi "https://doi.org/10.1016/j.femsyr.2004.04.005" @default.
• W2126959065 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15489194" @default.
• W2126959065 hasPublicationYear "2004" @default.
• W2126959065 type Work @default.
• W2126959065 sameAs 2126959065 @default.
• W2126959065 citedByCount "36" @default.
• W2126959065 countsByYear W21269590652012 @default.
• W2126959065 countsByYear W21269590652013 @default.
• W2126959065 countsByYear W21269590652014 @default.
• W2126959065 countsByYear W21269590652015 @default.
• W2126959065 countsByYear W21269590652016 @default.
• W2126959065 countsByYear W21269590652017 @default.
• W2126959065 countsByYear W21269590652018 @default.
• W2126959065 countsByYear W21269590652019 @default.
• W2126959065 crossrefType "journal-article" @default.
• W2126959065 hasAuthorship W2126959065A5025480370 @default.
• W2126959065 hasBestOaLocation W21269590651 @default.
• W2126959065 hasConcept C104317684 @default.
• W2126959065 hasConcept C141231307 @default.
• W2126959065 hasConcept C194082555 @default.
• W2126959065 hasConcept C24586158 @default.
• W2126959065 hasConcept C2776759703 @default.
• W2126959065 hasConcept C2777576037 @default.
• W2126959065 hasConcept C2779222958 @default.
• W2126959065 hasConcept C28859421 @default.
• W2126959065 hasConcept C54355233 @default.
• W2126959065 hasConcept C75385678 @default.
• W2126959065 hasConcept C86803240 @default.
• W2126959065 hasConcept C89684784 @default.
• W2126959065 hasConcept C95444343 @default.
• W2126959065 hasConceptScore W2126959065C104317684 @default.
• W2126959065 hasConceptScore W2126959065C141231307 @default.
• W2126959065 hasConceptScore W2126959065C194082555 @default.
• W2126959065 hasConceptScore W2126959065C24586158 @default.
• W2126959065 hasConceptScore W2126959065C2776759703 @default.
• W2126959065 hasConceptScore W2126959065C2777576037 @default.
• W2126959065 hasConceptScore W2126959065C2779222958 @default.
• W2126959065 hasConceptScore W2126959065C28859421 @default.
• W2126959065 hasConceptScore W2126959065C54355233 @default.
• W2126959065 hasConceptScore W2126959065C75385678 @default.
• W2126959065 hasConceptScore W2126959065C86803240 @default.
• W2126959065 hasConceptScore W2126959065C89684784 @default.
• W2126959065 hasConceptScore W2126959065C95444343 @default.

• next