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- W2126967198 abstract "In muscle cells, part of the calcium is tightly bound to the N1‐ and N2‐line of the sarcomere but its physiological significance was unknown. In the present work we reported the ability of a recombinant titin fragment spanning titin domains Z9 to I1 to tightly bind calcium ions with a K d of 0.049±0.004 nM. We further showed that calcium induced a spontaneous aggregation of the titin fragment and that the major aggregate is a tetramer. The implication of these findings on the organization of the six titin strands that emanate from the end of the thick filament within the I‐band is discussed." @default.
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- W2126967198 date "2003-12-11" @default.
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- W2126967198 title "Myofibrillar tightly bound calcium in skeletal muscle fibers: a possible role of this cation in titin strands aggregation" @default.
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- W2126967198 doi "https://doi.org/10.1016/s0014-5793(03)01436-4" @default.
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