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• W2126970339 abstract "Prokaryotes and eukaryotes synthesize long chains of orthophosphate, known as polyphosphate (polyP), which form dense granules within the cell. PolyP regulates myriad cellular functions and is often localized to specific subcellular addresses through mechanisms that remain undefined. In this study, we present a molecular-level analysis of polyP subcellular localization in the model bacterium Caulobacter crescentus. We demonstrate that biogenesis and localization of polyP is controlled as a function of the cell cycle, which ensures regular partitioning of granules between mother and daughter. The enzyme polyphosphate kinase 1 (Ppk1) is required for granule production, colocalizes with granules, and dynamically localizes to the sites of new granule synthesis in nascent daughter cells. Localization of Ppk1 within the cell requires an intact catalytic active site and a short, positively charged tail at the C-terminus of the protein. The processes of chromosome replication and segregation govern both the number and position of Ppk1/polyP complexes within the cell. We propose a multistep model in which the chromosome establishes sites of polyP coalescence, which recruit Ppk1 to promote the in situ synthesis of large granules. These findings underscore the importance of both chromosome dynamics and discrete protein localization as organizing factors in bacterial cell biology." @default.
• W2126970339 created "2016-06-24" @default.
• W2126970339 creator A5068647102 @default.
• W2126970339 creator A5089823491 @default.
• W2126970339 date "2013-10-15" @default.
• W2126970339 modified "2023-09-28" @default.
• W2126970339 title "Chromosome replication and segregation govern the biogenesis and inheritance of inorganic polyphosphate granules" @default.
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• W2126970339 doi "https://doi.org/10.1091/mbc.e13-04-0182" @default.
• W2126970339 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3806658" @default.
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• W2126970339 hasPublicationYear "2013" @default.
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