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- W2126990943 abstract "Cells rely on the coordinated regulation of lipid phosphoinositides and Rab GTPases to define membrane compartment fates along distinct trafficking routes. The family of disease-related myotubularin (MTM) phosphoinositide phosphatases includes catalytically inactive members, or pseudophosphatases, with poorly understood functions. We found that Drosophila MTM pseudophosphatase Sbf coordinates both phosphatidylinositol 3-phosphate (PI(3)P) turnover and Rab21 GTPase activation in an endosomal pathway that controls macrophage remodeling. Sbf dynamically interacts with class II phosphatidylinositol 3-kinase and stably recruits Mtm to promote turnover of a PI(3)P subpool essential for endosomal trafficking. Sbf also functions as a guanine nucleotide exchange factor that promotes Rab21 GTPase activation associated with PI(3)P endosomes. Of importance, Sbf, Mtm, and Rab21 function together, along with Rab11-mediated endosomal trafficking, to control macrophage protrusion formation. This identifies Sbf as a critical coordinator of PI(3)P and Rab21 regulation, which specifies an endosomal pathway and cortical control." @default.
- W2126990943 created "2016-06-24" @default.
- W2126990943 creator A5015799919 @default.
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- W2126990943 creator A5020140046 @default.
- W2126990943 creator A5023101923 @default.
- W2126990943 creator A5061056170 @default.
- W2126990943 date "2012-07-15" @default.
- W2126990943 modified "2023-09-26" @default.
- W2126990943 title "Sbf/MTMR13 coordinates PI(3)P and Rab21 regulation in endocytic control of cellular remodeling" @default.
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- W2126990943 doi "https://doi.org/10.1091/mbc.e12-05-0375" @default.
- W2126990943 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3395661" @default.
- W2126990943 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22648168" @default.
- W2126990943 hasPublicationYear "2012" @default.
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