FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2126991211> ?p ?o ?g. }

• W2126991211 endingPage "1410" @default.
• W2126991211 startingPage "1401" @default.
• W2126991211 abstract "Abstract Miniaturized microneedle devices are being developed for painlessly targeting vaccines to the immune cell populations in skin. As skin immunization studies are generally restricted to animal models however, where skin architecture and immunity is greatly different to human, surprisingly little is known about the local human response to intradermal (ID) vaccines. Here surgically excised human skin is used to explore for the first time the complex molecular and cellular host responses to a candidate influenza vaccine comprising nanoparticulate virus‐like‐particles (VLPs), administered via conventional hypodermic injection or reduced scale microneedles. Responses at the molecular level are determined by microarray analysis (47,296 discrete transcripts) and validated by quantitative PCR (96 genes). Cellular response is probed through monitoring migration of dendritic cells in viable skin tissue. Gene expression mapping, ontological analysis, and qPCR reveal up‐regulation of a host of genes responsible for key immunomodulatory processes and host viral response, including cell recruitment, activation, migration, and T cell interaction following both ID and microneedle injection of VLPs; the response from the microneedles being more subtle. Significant morphological and migratory changes to skin dendritic cells are also apparent following microneedle VLP delivery. This is the first study displaying the global, multifaceted immunological events that occur at the site of vaccine deposition in human skin and will subsequently influence the degree and nature of innate and adaptive immune responses. An increased understanding of the detailed similarities and differences in response against antigen administered via different delivery modalities will inform the development of improved vaccines and vaccine delivery systems." @default.
• W2126991211 created "2016-06-24" @default.
• W2126991211 creator A5001788944 @default.
• W2126991211 creator A5003344100 @default.
• W2126991211 creator A5074946126 @default.
• W2126991211 creator A5080218937 @default.
• W2126991211 creator A5091280121 @default.
• W2126991211 date "2013-04-08" @default.
• W2126991211 modified "2023-10-16" @default.
• W2126991211 title "Host Responses in Human Skin After Conventional Intradermal Injection or Microneedle Administration of Virus-Like-Particle Influenza Vaccine" @default.
• W2126991211 cites W1794865292 @default.
• W2126991211 cites W1905216348 @default.
• W2126991211 cites W1969184940 @default.
• W2126991211 cites W1970065596 @default.
• W2126991211 cites W1971863415 @default.
• W2126991211 cites W1975579793 @default.
• W2126991211 cites W1976076274 @default.
• W2126991211 cites W1976846800 @default.
• W2126991211 cites W1986034785 @default.
• W2126991211 cites W1991202374 @default.
• W2126991211 cites W1993251220 @default.
• W2126991211 cites W1995234326 @default.
• W2126991211 cites W2000574141 @default.
• W2126991211 cites W2003575753 @default.
• W2126991211 cites W2007539416 @default.
• W2126991211 cites W2007670470 @default.
• W2126991211 cites W2021186851 @default.
• W2126991211 cites W2024490058 @default.
• W2126991211 cites W2039467806 @default.
• W2126991211 cites W2041912408 @default.
• W2126991211 cites W2043308790 @default.
• W2126991211 cites W2044220667 @default.
• W2126991211 cites W2050922241 @default.
• W2126991211 cites W2066442197 @default.
• W2126991211 cites W2068741025 @default.
• W2126991211 cites W2072371434 @default.
• W2126991211 cites W2078142696 @default.
• W2126991211 cites W2092077397 @default.
• W2126991211 cites W2098070967 @default.
• W2126991211 cites W2103565638 @default.
• W2126991211 cites W2106865625 @default.
• W2126991211 cites W2108751995 @default.
• W2126991211 cites W2109963121 @default.
• W2126991211 cites W2111134404 @default.
• W2126991211 cites W2116058039 @default.
• W2126991211 cites W2118873626 @default.
• W2126991211 cites W2119626086 @default.
• W2126991211 cites W2133160112 @default.
• W2126991211 cites W2142669484 @default.
• W2126991211 cites W2148727825 @default.
• W2126991211 cites W2148740102 @default.
• W2126991211 cites W2149821903 @default.
• W2126991211 cites W2156313733 @default.
• W2126991211 cites W2156472928 @default.
• W2126991211 cites W2161091532 @default.
• W2126991211 cites W2162440799 @default.
• W2126991211 cites W2164707561 @default.
• W2126991211 cites W2165933648 @default.
• W2126991211 cites W2166140642 @default.
• W2126991211 cites W231716781 @default.
• W2126991211 cites W25898841 @default.
• W2126991211 doi "https://doi.org/10.1002/adhm.201300006" @default.
• W2126991211 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4009496" @default.
• W2126991211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23564440" @default.
• W2126991211 hasPublicationYear "2013" @default.
• W2126991211 type Work @default.
• W2126991211 sameAs 2126991211 @default.
• W2126991211 citedByCount "32" @default.
• W2126991211 countsByYear W21269912112013 @default.
• W2126991211 countsByYear W21269912112014 @default.
• W2126991211 countsByYear W21269912112015 @default.
• W2126991211 countsByYear W21269912112016 @default.
• W2126991211 countsByYear W21269912112017 @default.
• W2126991211 countsByYear W21269912112018 @default.
• W2126991211 countsByYear W21269912112019 @default.
• W2126991211 countsByYear W21269912112021 @default.
• W2126991211 countsByYear W21269912112022 @default.
• W2126991211 crossrefType "journal-article" @default.
• W2126991211 hasAuthorship W2126991211A5001788944 @default.
• W2126991211 hasAuthorship W2126991211A5003344100 @default.
• W2126991211 hasAuthorship W2126991211A5074946126 @default.
• W2126991211 hasAuthorship W2126991211A5080218937 @default.
• W2126991211 hasAuthorship W2126991211A5091280121 @default.
• W2126991211 hasBestOaLocation W21269912112 @default.
• W2126991211 hasConcept C159047783 @default.
• W2126991211 hasConcept C203014093 @default.
• W2126991211 hasConcept C2522874641 @default.
• W2126991211 hasConcept C2777459323 @default.
• W2126991211 hasConcept C2778170410 @default.
• W2126991211 hasConcept C2780689484 @default.
• W2126991211 hasConcept C54355233 @default.
• W2126991211 hasConcept C71924100 @default.
• W2126991211 hasConcept C86803240 @default.
• W2126991211 hasConcept C8891405 @default.
• W2126991211 hasConceptScore W2126991211C159047783 @default.
• W2126991211 hasConceptScore W2126991211C203014093 @default.
• W2126991211 hasConceptScore W2126991211C2522874641 @default.
• W2126991211 hasConceptScore W2126991211C2777459323 @default.

• next