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• W2126994908 abstract "Several conditions have been identified as precursors of gastric cancer. The most common of these is intestinal metaplasia (IM) accompanying atrophic antral gastritis (Type B gastritis) in countries at high risk for gastric carcinoma (Japan, Eastern Europe, Western South America). The risk for this tumor is acquired in youth and persists into old age even if the person migrates away from the high risk area. It has been linked to a diet containing large amounts of salt and nitrate; but lacking in Vitamins C and E. The next most common high risk condition is atrophic gastritis with IM of the oxyntic mucosa accompanying pernicious anemia (Type A gastritis). This disease is most common in Northern Europe. Carcinoma accompanying intestinal metaplasia is usually intestinal in type; and induction of both IM and cancer have been attributed to the action of nitroso compounds in the gastric juice. These could be formed by nitrosation of dietary amines, a process that is blocked by Vitamins C and E. Diffuse gastric carcinoma occurs in younger persons who have little or no IM. It is less responsive to environmental changes and is most common in patients with blood Type A. Such persons may have inherited increased susceptibility to environmental carcinogens so that a small dose could generate invasive carcinoma with no intermediate stage of IM, as may occur in experimental animals given large doses of nitroso compounds. If gastric carcinoma induction follows repeated mutagenic events, dietary intervention might arrest the process at the level of IM. This could take the form of daily use of Vitamins C and E, and reduced consumption of salt. Recognition of high risk groups might identify persons that might be usefully subjected to periodic endoscopic screening (e.g., every 5 years)." @default.
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• W2126994908 date "1981-03-01" @default.
• W2126994908 modified "2023-10-05" @default.
• W2126994908 title "The impact of epidemiology upon the diagnosis and management of gastric disease: the experience of the Hawaii Japanese" @default.
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• W2126994908 doi "https://doi.org/10.1007/bf02967286" @default.
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