FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2127003822> ?p ?o ?g. }

• W2127003822 endingPage "787" @default.
• W2127003822 startingPage "782" @default.
• W2127003822 abstract "In humans, active renin is generated by the removal of a 43-amino acid prosegment from the zymogen prorenin. This cleavage event is highly specific, occurring at only one of the seven pairs of basic amino acids in the body of preprorenin. This cleavage site selectivity is also displayed by a number of other proteases in vitro and in mouse pituitary AtT-20 cells transfected with a human preprorenin expression vector, suggesting that specificity of cleavage is directed in part by the primary sequence, the higher order structure, or both of prorenin itself. To test this hypothesis, single amino acid mutations were introduced in the region of human preprorenin surrounding the natural cleavage site, and the resultant recombinant proteins were expressed in cultured Chinese hamster ovary and AtT-20 cells. The results suggest that amino acids in addition to the pair of basic amino acids surrounding the cleavage site affect the ability of both trypsin and the endogenous AtT-20 processing enzyme to cleave prorenin. Notably, although a proline at position -4 is essential for processing of prorenin in AtT-20 cells and is correlated with predicted formation of a beta-turn at this position, site-directed mutations suggest that this structural feature in addition to a pair of basic amino acids is not sufficient to lead to proteolytic activation of prorenin. Displacement of sequences surrounding the cleavage site to a position 10 amino acids toward the amino terminus led to partial processing of a mutated prorenin.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
• W2127003822 created "2016-06-24" @default.
• W2127003822 creator A5004876560 @default.
• W2127003822 creator A5019575527 @default.
• W2127003822 creator A5063192986 @default.
• W2127003822 creator A5083296600 @default.
• W2127003822 date "1992-12-01" @default.
• W2127003822 modified "2023-10-15" @default.
• W2127003822 title "Molecular determinants of human prorenin processing." @default.
• W2127003822 cites W1482788894 @default.
• W2127003822 cites W1518346105 @default.
• W2127003822 cites W1538634378 @default.
• W2127003822 cites W1540687701 @default.
• W2127003822 cites W1541743572 @default.
• W2127003822 cites W1563019217 @default.
• W2127003822 cites W1567637030 @default.
• W2127003822 cites W1883375123 @default.
• W2127003822 cites W1969477781 @default.
• W2127003822 cites W1984130311 @default.
• W2127003822 cites W1984247755 @default.
• W2127003822 cites W1992589321 @default.
• W2127003822 cites W2007253790 @default.
• W2127003822 cites W2008862069 @default.
• W2127003822 cites W2026167342 @default.
• W2127003822 cites W2031254987 @default.
• W2127003822 cites W2053819105 @default.
• W2127003822 cites W2085902346 @default.
• W2127003822 cites W2095450147 @default.
• W2127003822 cites W2114314867 @default.
• W2127003822 cites W2126719129 @default.
• W2127003822 cites W2146721491 @default.
• W2127003822 cites W2161121534 @default.
• W2127003822 cites W2162403411 @default.
• W2127003822 cites W2396681767 @default.
• W2127003822 cites W2425821490 @default.
• W2127003822 cites W2886017093 @default.
• W2127003822 cites W4211064734 @default.
• W2127003822 cites W85005567 @default.
• W2127003822 doi "https://doi.org/10.1161/01.hyp.20.6.782" @default.
• W2127003822 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1452293" @default.
• W2127003822 hasPublicationYear "1992" @default.
• W2127003822 type Work @default.
• W2127003822 sameAs 2127003822 @default.
• W2127003822 citedByCount "11" @default.
• W2127003822 countsByYear W21270038222014 @default.
• W2127003822 countsByYear W21270038222018 @default.
• W2127003822 crossrefType "journal-article" @default.
• W2127003822 hasAuthorship W2127003822A5004876560 @default.
• W2127003822 hasAuthorship W2127003822A5019575527 @default.
• W2127003822 hasAuthorship W2127003822A5063192986 @default.
• W2127003822 hasAuthorship W2127003822A5083296600 @default.
• W2127003822 hasBestOaLocation W21270038221 @default.
• W2127003822 hasConcept C104317684 @default.
• W2127003822 hasConcept C151730666 @default.
• W2127003822 hasConcept C153911025 @default.
• W2127003822 hasConcept C167625842 @default.
• W2127003822 hasConcept C170493617 @default.
• W2127003822 hasConcept C175156509 @default.
• W2127003822 hasConcept C175656101 @default.
• W2127003822 hasConcept C181199279 @default.
• W2127003822 hasConcept C182220744 @default.
• W2127003822 hasConcept C185592680 @default.
• W2127003822 hasConcept C2777265534 @default.
• W2127003822 hasConcept C2778163477 @default.
• W2127003822 hasConcept C2780072125 @default.
• W2127003822 hasConcept C2908627167 @default.
• W2127003822 hasConcept C43369102 @default.
• W2127003822 hasConcept C43554185 @default.
• W2127003822 hasConcept C515207424 @default.
• W2127003822 hasConcept C55493867 @default.
• W2127003822 hasConcept C86803240 @default.
• W2127003822 hasConceptScore W2127003822C104317684 @default.
• W2127003822 hasConceptScore W2127003822C151730666 @default.
• W2127003822 hasConceptScore W2127003822C153911025 @default.
• W2127003822 hasConceptScore W2127003822C167625842 @default.
• W2127003822 hasConceptScore W2127003822C170493617 @default.
• W2127003822 hasConceptScore W2127003822C175156509 @default.
• W2127003822 hasConceptScore W2127003822C175656101 @default.
• W2127003822 hasConceptScore W2127003822C181199279 @default.
• W2127003822 hasConceptScore W2127003822C182220744 @default.
• W2127003822 hasConceptScore W2127003822C185592680 @default.
• W2127003822 hasConceptScore W2127003822C2777265534 @default.
• W2127003822 hasConceptScore W2127003822C2778163477 @default.
• W2127003822 hasConceptScore W2127003822C2780072125 @default.
• W2127003822 hasConceptScore W2127003822C2908627167 @default.
• W2127003822 hasConceptScore W2127003822C43369102 @default.
• W2127003822 hasConceptScore W2127003822C43554185 @default.
• W2127003822 hasConceptScore W2127003822C515207424 @default.
• W2127003822 hasConceptScore W2127003822C55493867 @default.
• W2127003822 hasConceptScore W2127003822C86803240 @default.
• W2127003822 hasIssue "6" @default.
• W2127003822 hasLocation W21270038221 @default.
• W2127003822 hasLocation W21270038222 @default.
• W2127003822 hasLocation W21270038223 @default.
• W2127003822 hasOpenAccess W2127003822 @default.
• W2127003822 hasPrimaryLocation W21270038221 @default.
• W2127003822 hasRelatedWork W1568178986 @default.
• W2127003822 hasRelatedWork W2023374250 @default.

• next