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• W2127013244 startingPage "1396" @default.
• W2127013244 abstract "The phosphorylation of a protein on multiple sites has been proposed to promote the switchlike regulation of protein activity. Recent theoretical work, however, indicates that multisite phosphorylation, by itself, is less effective at creating switchlike responses than had been previously thought. The phosphorylation of a protein often alters its spatial localization, or its association with other proteins, and this sequestration can alter the accessibility of the substrate to the relevant kinases and phosphatases. Sequestration thus has the potential to interact with multisite phosphorylation to modulate ultrasensitivity and threshold. Here, using simple ordinary differential equations to represent phosphorylation, dephosphorylation, and binding/sequestration, we demonstrate that the combination of multisite phosphorylation and regulated substrate sequestration can produce a response that is both a good threshold and a good switch. Several strategies are explored, including both stronger and weaker sequestration with successive phosphorylations, as well as combinations that are more elaborate. In some strategies, such as when phosphorylation and dephosphorylation are segregated, a near-optimal switch is possible, where the effective Hill number equals the number of phosphorylation sites." @default.
• W2127013244 created "2016-06-24" @default.
• W2127013244 creator A5025564811 @default.
• W2127013244 creator A5076311980 @default.
• W2127013244 creator A5079448426 @default.
• W2127013244 date "2010-04-01" @default.
• W2127013244 modified "2023-09-23" @default.
• W2127013244 title "A Combination of Multisite Phosphorylation and Substrate Sequestration Produces Switchlike Responses" @default.
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• W2127013244 doi "https://doi.org/10.1016/j.bpj.2009.12.4307" @default.
• W2127013244 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2856190" @default.
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• W2127013244 hasPublicationYear "2010" @default.
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