FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2127015685> ?p ?o ?g. }

• W2127015685 endingPage "33" @default.
• W2127015685 startingPage "30" @default.
• W2127015685 abstract "OBJECTIVES--To determine the anti-ischaemic effects of a new angiotensin converting enzyme inhibitor, benazepril, compared with nifedipine, alone and in combination, in chronic stable angina caused by coronary artery disease. DESIGN--Placebo controlled, double blind, latin square design. SETTING--Regional cardiology service for a mixed urban and rural population. SUBJECTS--40 patients with stable exertional angina producing at least 1 mm ST segment depression on exercise test with the Bruce protocol. 34 patients completed all four phases of the trial. INTERVENTIONS--Each patient was treated with placebo, benazepril (10 mg twice daily), nifedipine retard (20 mg twice daily), and a combination of benazepril and nifedipine in the same doses, in random order for periods of two weeks. MAIN OUTCOME MEASURES AND RESULTS--Total duration of exercise was not increased by any treatment. Exercise time to the development of 1 mm ST segment depression was not significantly changed with benazepril alone or in combination with nifedipine but was increased with nifedipine from 4.18 (1.8) min to 4.99 (1.6) min (95% confidence interval (95% CI) 0.28 to 1.34; p < 0.05). There was a significant relation between increase in duration of exercise and resting renin concentration (r = 0.498; p < 0.01). Myocardial ischaemia during daily activity, as assessed by ambulatory electrocardiographic monitoring, was reduced by benazepril and by the benazepril and nifedipine combination. This was significant for total ischaemic burden (451(628) min v 231(408) min; 95% CI -398 to -41 min; p < 0.05) and maximal depth of ST segment depression (-2.47(1.2) mm v -2.16 mm; 95% CI 0.04 to 0.57; p < 0.05) for the combination and for maximal ST segment depth for benazepril monotherapy (-2.47 (1.2) mm v -1.96(1.2) mm; 95% CI 0.18 to 0.91; p < 0.05). Benazepril significantly altered the circadian rhythm of cardiac ischaemia, abolishing the peak ischaemic periods at 0700 to 1200 and 1700 to 2300 (p < 0.05). CONCLUSIONS--Benazepril, an angiotensin converting enzyme inhibitor, had a modest anti-ischaemic effect in effort angina, but this effect was not as pronounced as with nifedipine. The anti-ischaemic action was more noticeable in asymptomatic ischaemia during daily activity, whereas nifedipine had little effect on this aspect of myocardial ischaemia. The combination of benazepril and nifedipine reduced ischaemia of daily activity." @default.
• W2127015685 created "2016-06-24" @default.
• W2127015685 creator A5015658421 @default.
• W2127015685 creator A5015920881 @default.
• W2127015685 creator A5017775651 @default.
• W2127015685 creator A5023004151 @default.
• W2127015685 creator A5027370048 @default.
• W2127015685 creator A5031262573 @default.
• W2127015685 creator A5054002857 @default.
• W2127015685 creator A5059910171 @default.
• W2127015685 date "1994-01-01" @default.
• W2127015685 modified "2023-09-26" @default.
• W2127015685 title "Angiotensin converting enzyme inhibition in chronic stable angina: effects on myocardial ischaemia and comparison with nifedipine." @default.
• W2127015685 cites W1966835068 @default.
• W2127015685 cites W1974946514 @default.
• W2127015685 cites W1994782683 @default.
• W2127015685 cites W1999065942 @default.
• W2127015685 cites W2009392253 @default.
• W2127015685 cites W2009647387 @default.
• W2127015685 cites W2033126268 @default.
• W2127015685 cites W2050650055 @default.
• W2127015685 cites W2050904644 @default.
• W2127015685 cites W2051353341 @default.
• W2127015685 cites W2052244137 @default.
• W2127015685 cites W2054301807 @default.
• W2127015685 cites W2055556050 @default.
• W2127015685 cites W2060000070 @default.
• W2127015685 cites W2062575903 @default.
• W2127015685 cites W2076778401 @default.
• W2127015685 cites W2077157858 @default.
• W2127015685 cites W2078141915 @default.
• W2127015685 cites W2082588294 @default.
• W2127015685 cites W2085780895 @default.
• W2127015685 cites W2092687360 @default.
• W2127015685 cites W2093671121 @default.
• W2127015685 cites W2112175766 @default.
• W2127015685 cites W2116950334 @default.
• W2127015685 cites W2214021235 @default.
• W2127015685 cites W2298497916 @default.
• W2127015685 cites W2313938778 @default.
• W2127015685 cites W2412283003 @default.
• W2127015685 cites W2434054623 @default.
• W2127015685 cites W34740527 @default.
• W2127015685 doi "https://doi.org/10.1136/hrt.71.1.30" @default.
• W2127015685 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/483605" @default.
• W2127015685 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8297690" @default.
• W2127015685 hasPublicationYear "1994" @default.
• W2127015685 type Work @default.
• W2127015685 sameAs 2127015685 @default.
• W2127015685 citedByCount "17" @default.
• W2127015685 crossrefType "journal-article" @default.
• W2127015685 hasAuthorship W2127015685A5015658421 @default.
• W2127015685 hasAuthorship W2127015685A5015920881 @default.
• W2127015685 hasAuthorship W2127015685A5017775651 @default.
• W2127015685 hasAuthorship W2127015685A5023004151 @default.
• W2127015685 hasAuthorship W2127015685A5027370048 @default.
• W2127015685 hasAuthorship W2127015685A5031262573 @default.
• W2127015685 hasAuthorship W2127015685A5054002857 @default.
• W2127015685 hasAuthorship W2127015685A5059910171 @default.
• W2127015685 hasBestOaLocation W21270156851 @default.
• W2127015685 hasConcept C126322002 @default.
• W2127015685 hasConcept C142724271 @default.
• W2127015685 hasConcept C164705383 @default.
• W2127015685 hasConcept C204787440 @default.
• W2127015685 hasConcept C27016395 @default.
• W2127015685 hasConcept C27081682 @default.
• W2127015685 hasConcept C2777363265 @default.
• W2127015685 hasConcept C2778213512 @default.
• W2127015685 hasConcept C2778425758 @default.
• W2127015685 hasConcept C2779066535 @default.
• W2127015685 hasConcept C2908647359 @default.
• W2127015685 hasConcept C35785553 @default.
• W2127015685 hasConcept C42219234 @default.
• W2127015685 hasConcept C500558357 @default.
• W2127015685 hasConcept C519063684 @default.
• W2127015685 hasConcept C71924100 @default.
• W2127015685 hasConcept C84393581 @default.
• W2127015685 hasConcept C99454951 @default.
• W2127015685 hasConceptScore W2127015685C126322002 @default.
• W2127015685 hasConceptScore W2127015685C142724271 @default.
• W2127015685 hasConceptScore W2127015685C164705383 @default.
• W2127015685 hasConceptScore W2127015685C204787440 @default.
• W2127015685 hasConceptScore W2127015685C27016395 @default.
• W2127015685 hasConceptScore W2127015685C27081682 @default.
• W2127015685 hasConceptScore W2127015685C2777363265 @default.
• W2127015685 hasConceptScore W2127015685C2778213512 @default.
• W2127015685 hasConceptScore W2127015685C2778425758 @default.
• W2127015685 hasConceptScore W2127015685C2779066535 @default.
• W2127015685 hasConceptScore W2127015685C2908647359 @default.
• W2127015685 hasConceptScore W2127015685C35785553 @default.
• W2127015685 hasConceptScore W2127015685C42219234 @default.
• W2127015685 hasConceptScore W2127015685C500558357 @default.
• W2127015685 hasConceptScore W2127015685C519063684 @default.
• W2127015685 hasConceptScore W2127015685C71924100 @default.
• W2127015685 hasConceptScore W2127015685C84393581 @default.
• W2127015685 hasConceptScore W2127015685C99454951 @default.
• W2127015685 hasIssue "1" @default.
• W2127015685 hasLocation W21270156851 @default.

• next