FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2127016570> ?p ?o ?g. }

• W2127016570 endingPage "34" @default.
• W2127016570 startingPage "32" @default.
• W2127016570 abstract "The objective of this research is to determine whether there are significant differences in the ¹⁸F-FDG produced by either the phosphate or the citrate buffer cassettes in the FASTlab synthesizer. <b>Methods:</b> Forty batches of ¹⁸F-FDG were produced with each cassette and analyzed retrospectively. The analysis consisted of determining the mean radiochemical yield (RCY)—uncorrected and corrected for decay—radiochemical purity (RCP), pH, and residual solvent content (ethanol and acetonitrile). An independent <i>t</i> test (alpha error [α], 0.05) was performed to determine whether the differences were statistically significant. <b>Results:</b> The mean decay-corrected RCYs for ¹⁸F-FDG produced by phosphate and citrate cassettes were 82.9% ± 17.4% and 79.2% ± 5.0%, respectively. The uncorrected RCY was 57.5% ± 16.7% for phosphate- and 58.8% ± 6.0% for citrate-buffered ¹⁸F-FDG, leading to a difference of 4.4% and <i>P</i> value of 0.11 for corrected RCY and a difference of 2.2% and <i>P</i> value of 0.32 for uncorrected RCY. Thus, the RCY differences are neither statistically nor clinically significant. The mean RCPs were 99.4% ± 0.2% for the phosphate-buffered ¹⁸F-FDG and 99.0% ± 1.1% for the citrate-buffered ¹⁸F-FDG. There was a 0.5% difference and a <i>P</i> value of 0.021, meaning that the difference was statistically significant. The average pHs for ¹⁸F-FDG produced by phosphate and citrate buffer cassettes were 5.9 ± 0.1 and 5.3 ± 0.2, respectively, resulting in a 9.6% difference and a <i>P</i> value close to zero (2.6 × 10⁻¹⁹)—a statistically significant difference. The difference between ethanol content was also dramatic. Phosphate-buffered ¹⁸F-FDG contained 0.08% ± 0.02% ethanol, whereas the citrate-buffered ¹⁸F-FDG contained 0.20% ± 0.07%. No difference was found in the acetonitrile content of the 2 cassettes. <b>Conclusion:</b> The differences in yield between cassettes are due to statistical variability. The results confirm our hypothesis that there is no significant difference in RCY. The differences seen in the statistically significant data (those with a <i>P</i> value > 0.05) turn out to be insignificant in a real-world setting because all values fell within the limits set by the United States Pharmacopeia and Food and Drug Administration. Therefore, determining which cassette to use is a matter of the preference of the institution." @default.
• W2127016570 created "2016-06-24" @default.
• W2127016570 creator A5004515708 @default.
• W2127016570 creator A5033512064 @default.
• W2127016570 creator A5051711123 @default.
• W2127016570 date "2013-01-14" @default.
• W2127016570 modified "2023-10-05" @default.
• W2127016570 title "Comparison of FASTlab 18F-FDG Production Using Phosphate and Citrate Buffer Cassettes" @default.
• W2127016570 cites W1579892113 @default.
• W2127016570 cites W1983808606 @default.
• W2127016570 cites W2145698745 @default.
• W2127016570 cites W2435865034 @default.
• W2127016570 doi "https://doi.org/10.2967/jnmt.112.112649" @default.
• W2127016570 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23318199" @default.
• W2127016570 hasPublicationYear "2013" @default.
• W2127016570 type Work @default.
• W2127016570 sameAs 2127016570 @default.
• W2127016570 citedByCount "16" @default.
• W2127016570 countsByYear W21270165702015 @default.
• W2127016570 countsByYear W21270165702016 @default.
• W2127016570 countsByYear W21270165702017 @default.
• W2127016570 countsByYear W21270165702020 @default.
• W2127016570 countsByYear W21270165702021 @default.
• W2127016570 countsByYear W21270165702022 @default.
• W2127016570 countsByYear W21270165702023 @default.
• W2127016570 crossrefType "journal-article" @default.
• W2127016570 hasAuthorship W2127016570A5004515708 @default.
• W2127016570 hasAuthorship W2127016570A5033512064 @default.
• W2127016570 hasAuthorship W2127016570A5051711123 @default.
• W2127016570 hasBestOaLocation W21270165701 @default.
• W2127016570 hasConcept C126322002 @default.
• W2127016570 hasConcept C13965031 @default.
• W2127016570 hasConcept C177322064 @default.
• W2127016570 hasConcept C178790620 @default.
• W2127016570 hasConcept C185592680 @default.
• W2127016570 hasConcept C2777132085 @default.
• W2127016570 hasConcept C2780161600 @default.
• W2127016570 hasConcept C2908528312 @default.
• W2127016570 hasConcept C2989005 @default.
• W2127016570 hasConcept C3018023364 @default.
• W2127016570 hasConcept C71924100 @default.
• W2127016570 hasConceptScore W2127016570C126322002 @default.
• W2127016570 hasConceptScore W2127016570C13965031 @default.
• W2127016570 hasConceptScore W2127016570C177322064 @default.
• W2127016570 hasConceptScore W2127016570C178790620 @default.
• W2127016570 hasConceptScore W2127016570C185592680 @default.
• W2127016570 hasConceptScore W2127016570C2777132085 @default.
• W2127016570 hasConceptScore W2127016570C2780161600 @default.
• W2127016570 hasConceptScore W2127016570C2908528312 @default.
• W2127016570 hasConceptScore W2127016570C2989005 @default.
• W2127016570 hasConceptScore W2127016570C3018023364 @default.
• W2127016570 hasConceptScore W2127016570C71924100 @default.
• W2127016570 hasIssue "1" @default.
• W2127016570 hasLocation W21270165701 @default.
• W2127016570 hasLocation W21270165702 @default.
• W2127016570 hasOpenAccess W2127016570 @default.
• W2127016570 hasPrimaryLocation W21270165701 @default.
• W2127016570 hasRelatedWork W1975141418 @default.
• W2127016570 hasRelatedWork W2001960069 @default.
• W2127016570 hasRelatedWork W2009230434 @default.
• W2127016570 hasRelatedWork W2033505165 @default.
• W2127016570 hasRelatedWork W2057457746 @default.
• W2127016570 hasRelatedWork W2134702784 @default.
• W2127016570 hasRelatedWork W2951805389 @default.
• W2127016570 hasRelatedWork W2952273270 @default.
• W2127016570 hasRelatedWork W3134956769 @default.
• W2127016570 hasRelatedWork W4288785686 @default.
• W2127016570 hasVolume "41" @default.
• W2127016570 isParatext "false" @default.
• W2127016570 isRetracted "false" @default.
• W2127016570 magId "2127016570" @default.
• W2127016570 workType "article" @default.