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• W2127023470 startingPage "10923" @default.
• W2127023470 abstract "Night (scotopic) vision is mediated by a distinct retinal circuit in which the light responses of rod-driven neurons are faster than those of the rods themselves. To investigate the dynamics of synaptic transmission at the second synapse in the rod pathway, we made paired voltage-clamp recordings from rod bipolar cells (RBCs) and postsynaptic AII and A17 amacrine cells in rat retinal slices. Depolarization of RBCs from -60 mV elicited sustained Ca 2+ currents and evoked AMPA receptor (AMPAR)-mediated EPSCs in synaptically coupled amacrine cells that exhibited large, rapidly rising initial peaks that decayed rapidly to smaller, steady-state levels. The transient component persisted in the absence of feedback inhibition to the RBC terminal and when postsynaptic AMPA receptor desensitization was blocked with cyclothiazide, indicating that it reflects a time-dependent decrease in the rate of exocytosis from the presynaptic terminal. The EPSC waveform was similar when RBCs were recorded in perforated-patch or whole-cell configurations, but asynchronous release from RBCs was enhanced when the intraterminal Ca 2+ buffer capacity was reduced. When RBCs were depolarized from -100 mV, inactivating, low voltage-activated (T-type channel-mediated) Ca 2+ currents were evident. Although Ca 2+ influx through T-type channels boosted vesicle release, as reflected by larger EPSCs, it did not make the EPSCs faster, indicating that activation of T-type channels is not necessary to generate a transient phase of exocytosis. We conclude that the time course of vesicle release from RBCs is inherently transient and, together with the fast kinetics of postsynaptic AMPARs, speeds transmission at this synapse." @default.
• W2127023470 created "2016-06-24" @default.
• W2127023470 creator A5011748503 @default.
• W2127023470 creator A5080645328 @default.
• W2127023470 date "2003-11-26" @default.
• W2127023470 modified "2023-10-12" @default.
• W2127023470 title "Sustained Ca²⁺Entry Elicits Transient Postsynaptic Currents at a Retinal Ribbon Synapse" @default.
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• W2127023470 doi "https://doi.org/10.1523/jneurosci.23-34-10923.2003" @default.
• W2127023470 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6740976" @default.
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