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- W2127029216 abstract "Background and Aims: The aim of this study was to investigate relationship between electronomicroscopic, morphometrical and cytogenetic changes of hepatocytes and insulin resistance (IR), adipokine profile and tumour necrosis factor-alpha (TNFa) in NASH patients. Methods: In 36 NASH patients [age, 46.7±7.5 yr; body mass index (BMI), 32.4±4.9 kg/m] and 12 healthy volunteers [age, 44.3±5.5 yr; BMI, 24.2±2.8 kg/m] obesity and IR were determined by BMI and HOMA-IR. Circulating levels of insulin, leptin, adiponectin, TNFa levels were measured by immuno-assay method. In addition, electronomicroscopic, morphometrical and cytogenetic examinations of the hepatocytes and hepatocytes nuclears were investigated. Results: In NASH patients nuclears had irregular forms with diverticulums and invaginations of karyolemma, clearing up of matrices with electron density bodies and inclusions, local dilatations of perinuclear spatium and focal destroyed nuclear membranes. The condensed chromatin content (CCC) was increased in hepatocytes nuclear (p < 0.05). The quantity of the pathologically changed nuclears (QPCN) was increased in hepatocytes more than 2.9 times (p < 0.05) vs. control. The area of the hepatocytes profile (AHP) was significantly decreasing – up to (136.42±32.55)mm2 vs. (182.17±2.54)mm2 (p < 0.05) in the control. 28 (77.7%) NASH patients have AHP from 50.0 to 150.0mm, while in healthy volunteers this parameter was significantly higher: from 100.0 to 250.0mm (85.42%). This may be linked to the decreasing of the liver parenchyma. The area of the nuclear profile (ANP) of NAHS patients was significantly decreasing (up to 22.30±5.47mm2) (p < 0.05) vs. (35.32±0.60)mm2 in control. HOMA score correlated with CCC (P < 0.05) and QPCN (P < 0.01) and negatively – with AHP (P < 0.02) and ANP (P < 0.01). TNFa and leptin levels correlated with QPCN (P < 0.001 and P < 0.01) and negatively – with AHP (P < 0.001 and 0.02) and ANP (P < 0.01 and 0.03) and adiponectin levels correlated with AHP (P < 0.01) and ANP (P < 0.02) and negatively – with QPCN (P < 0.01). Conclusions: This study demonstrates the relationship between IR, adipokine profile, TNFa and electronomicroscopic, morphometrical and cytogenetic markers of the hepatocytes and hepatocytes nuclears in NASH patients." @default.
- W2127029216 created "2016-06-24" @default.
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- W2127029216 date "2011-03-01" @default.
- W2127029216 modified "2023-09-27" @default.
- W2127029216 title "875 HEPATOCYTES CHANGES IN NASH PATIENTS" @default.
- W2127029216 doi "https://doi.org/10.1016/s0168-8278(11)60877-5" @default.
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