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- W2127029855 abstract "Lamotrigine (LTG), a wide-spectrum antiepileptic drug, is derived from the dihydrofolate reductase inhibitor class of compounds and is thought to act mainly through blocking the influx of sodium ions, thereby reducing excess glutamate release and stabilizing neuronal membranes ( 1 Leach M.J. Marden C.M. Miller A.A. Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: II. Neurochemical studies on the mechanism of action. Epilepsia. 1986; 27: 490-497 Crossref PubMed Scopus (495) Google Scholar ). It is effective as an adjunctive treatment of refractory partial seizures and idiopathic generalized epilepsy in adults and children ( 2 French J.A. Kanner A.M. Bautista J. et al. Efficacy and tolerability of the new antiepileptic drugs II: treatment of refractory epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society. Neurology. 2004; 62: 1261-1273 Crossref PubMed Scopus (458) Google Scholar ). Rash has been reported as the most frequent side effect of LTG, whereas blood dyscrasias have been noted rarely ( 3 Mackay F.J. Wilton L.V. Pearce G.L. Freemantle S.N. Mann R.D. Safety of long-term lamotrigine in epilepsy. Epilepsia. 1997; 38: 881-886 Crossref PubMed Scopus (138) Google Scholar ). We report a boy who developed thrombocytopenia and leukopenia after receiving LTG for epilepsy." @default.
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- W2127029855 date "2012-05-01" @default.
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- W2127029855 title "Lamotrigine-associated Thrombocytopenia and Leukopenia" @default.
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- W2127029855 doi "https://doi.org/10.1016/j.jemermed.2010.05.060" @default.
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