FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2127035635> ?p ?o ?g. }

• W2127035635 endingPage "1100" @default.
• W2127035635 startingPage "1093" @default.
• W2127035635 abstract "In vivo glucocorticoid (GC) secretion exhibits a distinctive ultradian rhythmicity. The lipophilic hormone can rapidly diffuse into cells, although only the pulse peak is of sufficient amplitude to activate the low affinity glucocorticoid receptor (GR). Discrete pulses readily access brain regions such as the hippocampus where GR expression is enriched and known to regulate neuronal function, including memory and learning processes. In the present study, we have tested the hypothesis that GR brain targets are responsive to ultradian GC rhythmicity. We have used adrenalectomised rats replaced with pulses of corticosterone to determine the transcriptional effects of ultradian pulses in the hippocampus. Confocal microscopy confirmed that each GC pulse results in transient GR nuclear localisation in hippocampal CA1 neurones. Concomitant GR activation and DNA binding was demonstrated by synthetic glucocorticoid response element oligonucleotide binding, and verified for the Clock gene Period 1 promoter region by chromatin immunoprecipitation assays. Strikingly each GC pulse induced a 'burst' of transcription of Period 1 measured by heterogeneous nuclear RNA quantitative polymerase chain reaction. The net effect of pulsatile GC exposure on accumulation of the mature transcript was also assessed, revealing a plateau of mRNA levels throughout the time course of pulsatile exposure, indicating the pulse timing works optimally for steady state Per1 expression. The plateau dropped to baseline within 120 min of the final pulse, indicating a relatively short half-life for hippocampal Per1. The significance of this strict temporal control is that any perturbation to the pulse frequency or duration would have rapid quantitative effects on the levels of Per1. This in turn could affect hippocampal function, especially circadian related memory and learning processes." @default.
• W2127035635 created "2016-06-24" @default.
• W2127035635 creator A5017571758 @default.
• W2127035635 creator A5020351945 @default.
• W2127035635 creator A5027760499 @default.
• W2127035635 creator A5039900996 @default.
• W2127035635 creator A5045828654 @default.
• W2127035635 creator A5058974194 @default.
• W2127035635 creator A5067830519 @default.
• W2127035635 creator A5070987944 @default.
• W2127035635 date "2010-09-15" @default.
• W2127035635 modified "2023-10-16" @default.
• W2127035635 title "Glucocorticoid Ultradian Rhythmicity Directs Cyclical Gene Pulsing of the Clock Gene Period 1 in Rat Hippocampus" @default.
• W2127035635 cites W129023513 @default.
• W2127035635 cites W1509473298 @default.
• W2127035635 cites W1525852097 @default.
• W2127035635 cites W1529215334 @default.
• W2127035635 cites W1537033638 @default.
• W2127035635 cites W1971571464 @default.
• W2127035635 cites W1979971991 @default.
• W2127035635 cites W1982519328 @default.
• W2127035635 cites W1986130500 @default.
• W2127035635 cites W1986599980 @default.
• W2127035635 cites W1992592162 @default.
• W2127035635 cites W1993681199 @default.
• W2127035635 cites W1994398354 @default.
• W2127035635 cites W1998352623 @default.
• W2127035635 cites W2004736103 @default.
• W2127035635 cites W2021746160 @default.
• W2127035635 cites W2027335701 @default.
• W2127035635 cites W2031729266 @default.
• W2127035635 cites W2031996691 @default.
• W2127035635 cites W2037753553 @default.
• W2127035635 cites W2053621668 @default.
• W2127035635 cites W2054146939 @default.
• W2127035635 cites W2060925737 @default.
• W2127035635 cites W2062556981 @default.
• W2127035635 cites W2063394935 @default.
• W2127035635 cites W2064910482 @default.
• W2127035635 cites W2075627423 @default.
• W2127035635 cites W2077543304 @default.
• W2127035635 cites W2078689239 @default.
• W2127035635 cites W2087352541 @default.
• W2127035635 cites W2094075153 @default.
• W2127035635 cites W2096866573 @default.
• W2127035635 cites W2099555338 @default.
• W2127035635 cites W2105932111 @default.
• W2127035635 cites W2116629441 @default.
• W2127035635 cites W2118333948 @default.
• W2127035635 cites W2134406847 @default.
• W2127035635 cites W2137087294 @default.
• W2127035635 cites W2138881984 @default.
• W2127035635 cites W2139379365 @default.
• W2127035635 cites W2148022513 @default.
• W2127035635 cites W2151189356 @default.
• W2127035635 cites W2153433545 @default.
• W2127035635 cites W2154391625 @default.
• W2127035635 cites W2158983406 @default.
• W2127035635 cites W4234625062 @default.
• W2127035635 cites W4323238454 @default.
• W2127035635 doi "https://doi.org/10.1111/j.1365-2826.2010.02051.x" @default.
• W2127035635 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4968637" @default.
• W2127035635 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20649850" @default.
• W2127035635 hasPublicationYear "2010" @default.
• W2127035635 type Work @default.
• W2127035635 sameAs 2127035635 @default.
• W2127035635 citedByCount "124" @default.
• W2127035635 countsByYear W21270356352012 @default.
• W2127035635 countsByYear W21270356352013 @default.
• W2127035635 countsByYear W21270356352014 @default.
• W2127035635 countsByYear W21270356352015 @default.
• W2127035635 countsByYear W21270356352016 @default.
• W2127035635 countsByYear W21270356352017 @default.
• W2127035635 countsByYear W21270356352018 @default.
• W2127035635 countsByYear W21270356352019 @default.
• W2127035635 countsByYear W21270356352020 @default.
• W2127035635 countsByYear W21270356352021 @default.
• W2127035635 countsByYear W21270356352022 @default.
• W2127035635 countsByYear W21270356352023 @default.
• W2127035635 crossrefType "journal-article" @default.
• W2127035635 hasAuthorship W2127035635A5017571758 @default.
• W2127035635 hasAuthorship W2127035635A5020351945 @default.
• W2127035635 hasAuthorship W2127035635A5027760499 @default.
• W2127035635 hasAuthorship W2127035635A5039900996 @default.
• W2127035635 hasAuthorship W2127035635A5045828654 @default.
• W2127035635 hasAuthorship W2127035635A5058974194 @default.
• W2127035635 hasAuthorship W2127035635A5067830519 @default.
• W2127035635 hasAuthorship W2127035635A5070987944 @default.
• W2127035635 hasBestOaLocation W21270356352 @default.
• W2127035635 hasConcept C101762097 @default.
• W2127035635 hasConcept C104317684 @default.
• W2127035635 hasConcept C121446783 @default.
• W2127035635 hasConcept C126322002 @default.
• W2127035635 hasConcept C134018914 @default.
• W2127035635 hasConcept C134320426 @default.
• W2127035635 hasConcept C136792703 @default.
• W2127035635 hasConcept C148762608 @default.
• W2127035635 hasConcept C150194340 @default.

• next