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- W2127048351 abstract "Requirements for an in vitro secondary antibody response to the soluble antigens dinitrophenylated keyhole limpet hemocyanin and dinitrophenylated flow gamma-globulin are described for the clawed toad, Xenopus. Priming of both hapten and carrier-specific cells is required in order to obtain good responses to the hapten. The carrier-reactive (helper) cells do not adhere to nylon wool, are X ray-resistant and surface Ig-negative. The cell adherence and X ray sensitivity characteristics of these Xenopus T cells and their ability to generate a mixed lymphocyte response, allogeneic cytotoxic and helper activities, are identical to those of thymus-derived (T) cells in higher vertebrates. The hapten-reactive, antibody-secreting cell precursors are nylon-adherent, X ray-sensitive and surface Ig-positive. In the absence of other distinguishing serological markers for T cells in frogs, and considering the thymus dependency of the helper activity described here, the evidence presented is interpreted as demonstrating the requirement for antigen-specific T-B cell cooperation in response to soluble protein antigens in vitro for Xenopus." @default.
- W2127048351 created "2016-06-24" @default.
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- W2127048351 date "1980-11-01" @default.
- W2127048351 modified "2023-09-25" @default.
- W2127048351 title "In vitro evidence for T-B lymphocyte collaboration in the clawed toad,Xenopus" @default.
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- W2127048351 doi "https://doi.org/10.1002/eji.1830101112" @default.
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