Matches in SemOpenAlex for { <https://semopenalex.org/work/W2127050665> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2127050665 endingPage "612" @default.
- W2127050665 startingPage "606" @default.
- W2127050665 abstract "ABSTRACT Btn2p, a novel coiled-coil protein, is up-regulated in btn1 Δ yeast strains, and this up-regulation is thought to contribute to maintaining a stable vacuolar pH in btn1 Δ strains (D. A. Pearce, T. Ferea, S. A. Nosel, B. Das, and F. Sherman, Nat. Genet. 22: 55-58, 1999). We now report that Btn2p interacts biochemically and functionally with Rsg1p, a down-regulator of the Can1p arginine and lysine permease. Rsg1p localizes to a distinct structure toward the cell periphery, and strains lacking Btn2p ( btn2 Δ strains) fail to correctly localize Rsg1p. btn2 Δ strains, like rsg1 Δ strains, are sensitive for growth in the presence of the arginine analog canavanine. Furthermore, btn2 Δ strains, like rsg1 Δ strains, demonstrate an elevated rate of uptake of [ 14 C]arginine, which leads to increased intracellular levels of arginine. Overexpression of BTN2 results in a decreased rate of arginine uptake. Collectively, these results indicate that altered levels of Btn2p can modulate arginine uptake through localization of the Can1p-arginine permease regulatory protein, Rsg1p. Our original identification of Btn2p was that it is up-regulated in the btn1 Δ strain which serves as a model for the lysosomal storage disorder Batten disease. Btn1p is a vacuolar/lysosomal membrane protein, and btn1 Δ suppresses both the canavanine sensitivity and the elevated rate of uptake of arginine displayed by btn2 Δ rsg1 Δ strains. We conclude that Btn2p interacts with Rsg1p and modulates arginine uptake. Up-regulation of BTN2 expression in btn1 Δ strains may facilitate either a direct or indirect effect on intracellular arginine levels." @default.
- W2127050665 created "2016-06-24" @default.
- W2127050665 creator A5053038397 @default.
- W2127050665 creator A5080420128 @default.
- W2127050665 date "2002-08-01" @default.
- W2127050665 modified "2023-10-13" @default.
- W2127050665 title "Interaction with Btn2p Is Required for Localization of Rsg1p: Btn2p-Mediated Changes in Arginine Uptake in <i>Saccharomyces cerevisiae</i>" @default.
- W2127050665 cites W1503369988 @default.
- W2127050665 cites W1792278756 @default.
- W2127050665 cites W1996488187 @default.
- W2127050665 cites W2004595470 @default.
- W2127050665 cites W2005597116 @default.
- W2127050665 cites W2013297564 @default.
- W2127050665 cites W2042182494 @default.
- W2127050665 cites W2043453010 @default.
- W2127050665 cites W2067673948 @default.
- W2127050665 cites W2087346067 @default.
- W2127050665 cites W2088234686 @default.
- W2127050665 cites W2091117537 @default.
- W2127050665 cites W2101195413 @default.
- W2127050665 cites W2103523741 @default.
- W2127050665 cites W2130674504 @default.
- W2127050665 cites W2147955626 @default.
- W2127050665 cites W2149821695 @default.
- W2127050665 cites W2165298990 @default.
- W2127050665 cites W2170681065 @default.
- W2127050665 cites W2239538575 @default.
- W2127050665 doi "https://doi.org/10.1128/ec.1.4.606-612.2002" @default.
- W2127050665 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/117998" @default.
- W2127050665 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12456008" @default.
- W2127050665 hasPublicationYear "2002" @default.
- W2127050665 type Work @default.
- W2127050665 sameAs 2127050665 @default.
- W2127050665 citedByCount "39" @default.
- W2127050665 countsByYear W21270506652012 @default.
- W2127050665 countsByYear W21270506652013 @default.
- W2127050665 countsByYear W21270506652014 @default.
- W2127050665 countsByYear W21270506652015 @default.
- W2127050665 countsByYear W21270506652016 @default.
- W2127050665 countsByYear W21270506652017 @default.
- W2127050665 countsByYear W21270506652018 @default.
- W2127050665 countsByYear W21270506652019 @default.
- W2127050665 countsByYear W21270506652020 @default.
- W2127050665 crossrefType "journal-article" @default.
- W2127050665 hasAuthorship W2127050665A5053038397 @default.
- W2127050665 hasAuthorship W2127050665A5080420128 @default.
- W2127050665 hasBestOaLocation W21270506651 @default.
- W2127050665 hasConcept C102568950 @default.
- W2127050665 hasConcept C104317684 @default.
- W2127050665 hasConcept C149011108 @default.
- W2127050665 hasConcept C190062978 @default.
- W2127050665 hasConcept C190114821 @default.
- W2127050665 hasConcept C2776016237 @default.
- W2127050665 hasConcept C2777468819 @default.
- W2127050665 hasConcept C2777576037 @default.
- W2127050665 hasConcept C2777914855 @default.
- W2127050665 hasConcept C2779222958 @default.
- W2127050665 hasConcept C515207424 @default.
- W2127050665 hasConcept C55493867 @default.
- W2127050665 hasConcept C79879829 @default.
- W2127050665 hasConcept C86803240 @default.
- W2127050665 hasConcept C95444343 @default.
- W2127050665 hasConceptScore W2127050665C102568950 @default.
- W2127050665 hasConceptScore W2127050665C104317684 @default.
- W2127050665 hasConceptScore W2127050665C149011108 @default.
- W2127050665 hasConceptScore W2127050665C190062978 @default.
- W2127050665 hasConceptScore W2127050665C190114821 @default.
- W2127050665 hasConceptScore W2127050665C2776016237 @default.
- W2127050665 hasConceptScore W2127050665C2777468819 @default.
- W2127050665 hasConceptScore W2127050665C2777576037 @default.
- W2127050665 hasConceptScore W2127050665C2777914855 @default.
- W2127050665 hasConceptScore W2127050665C2779222958 @default.
- W2127050665 hasConceptScore W2127050665C515207424 @default.
- W2127050665 hasConceptScore W2127050665C55493867 @default.
- W2127050665 hasConceptScore W2127050665C79879829 @default.
- W2127050665 hasConceptScore W2127050665C86803240 @default.
- W2127050665 hasConceptScore W2127050665C95444343 @default.
- W2127050665 hasIssue "4" @default.
- W2127050665 hasLocation W21270506651 @default.
- W2127050665 hasLocation W21270506652 @default.
- W2127050665 hasLocation W21270506653 @default.
- W2127050665 hasOpenAccess W2127050665 @default.
- W2127050665 hasPrimaryLocation W21270506651 @default.
- W2127050665 hasRelatedWork W1225836934 @default.
- W2127050665 hasRelatedWork W1493347191 @default.
- W2127050665 hasRelatedWork W1505266621 @default.
- W2127050665 hasRelatedWork W1567969231 @default.
- W2127050665 hasRelatedWork W1682642099 @default.
- W2127050665 hasRelatedWork W188155302 @default.
- W2127050665 hasRelatedWork W2015247170 @default.
- W2127050665 hasRelatedWork W2037995085 @default.
- W2127050665 hasRelatedWork W2128236148 @default.
- W2127050665 hasRelatedWork W2343067289 @default.
- W2127050665 hasVolume "1" @default.
- W2127050665 isParatext "false" @default.
- W2127050665 isRetracted "false" @default.
- W2127050665 magId "2127050665" @default.
- W2127050665 workType "article" @default.