Matches in SemOpenAlex for { <https://semopenalex.org/work/W2127086674> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2127086674 endingPage "34" @default.
- W2127086674 startingPage "825" @default.
- W2127086674 abstract "An ovine model of osteoarthritis (OA) induced by bilateral lateral meniscectomy (BLM) was used to evaluate in vivo effects of the slow acting antiarthritic drug diacerein (DIA) on degenerative changes in cartilage and subchondral bone of the operated joints.Twenty of 30 adult age matched Merino wethers were subjected to BLM in the knee joints and the remainder served as non-operated controls (NOC). Half of the BLM group (n = 10) were given DIA (25 mg/kg orally) daily for 3 mo, then 50 mg/kg daily for a further 6 mo. The remainder of the meniscectomized (MEN) group served as OA controls. Five DIA, 5 MEN, and 5 NOC animals were sacrificed at 3 mo and the remainder at 9 mo postsurgery. One knee joint of each animal was used for bone mineral density (BMD) studies. Osteochondral slabs from the lateral femoral condyle and lateral tibial plateau were cut from the contralateral joint and were processed for histological and histomorphometric examination to assess the cartilage and subchondral bone changes.No significant difference was observed in the modified Mankin scores for cartilage from the DIA and MEN groups at 3 or 9 mo. However, in animals treated with DIA, the thickness of cartilage (p = 0.05) and subchondral bone (p = 0.05) in the lesion (middle) zone of the lateral tibial plateau were decreased relative to the corresponding zone of the MEN group at 3 mo (p = 0.05). At 9 mo subchondral bone thickness in this zone remained the same as NOC but BMD, which included both subchondral and trabecular bone, was significantly increased relative to the NOC group (p = 0.01). In contrast, the subchondral bone thickness of the outer zone of lateral tibial plateau and lateral femoral condyle of both MEN and DIA groups increased after 9 mo, while BMD remained the same as in the NOC.DIA treatment of meniscectomized animals mediated selective responses of cartilage and subchondral bone to the altered mechanical stresses induced across the joints by this procedure. While subchondral bone thickness in tibial lesion sites was reduced, cartilage and bone proliferation at the outer joint margins, a region where osteophyte formation occurred, were enhanced, suggesting that DIA supported the processes of repair and endochondral ossification." @default.
- W2127086674 created "2016-06-24" @default.
- W2127086674 creator A5025664015 @default.
- W2127086674 creator A5028034084 @default.
- W2127086674 creator A5035763329 @default.
- W2127086674 creator A5079128249 @default.
- W2127086674 date "2001-04-01" @default.
- W2127086674 modified "2023-10-02" @default.
- W2127086674 title "The effects of orally administered diacerein on cartilage and subchondral bone in an ovine model of osteoarthritis." @default.
- W2127086674 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11327258" @default.
- W2127086674 hasPublicationYear "2001" @default.
- W2127086674 type Work @default.
- W2127086674 sameAs 2127086674 @default.
- W2127086674 citedByCount "17" @default.
- W2127086674 countsByYear W21270866742015 @default.
- W2127086674 countsByYear W21270866742021 @default.
- W2127086674 countsByYear W21270866742022 @default.
- W2127086674 countsByYear W21270866742023 @default.
- W2127086674 crossrefType "journal-article" @default.
- W2127086674 hasAuthorship W2127086674A5025664015 @default.
- W2127086674 hasAuthorship W2127086674A5028034084 @default.
- W2127086674 hasAuthorship W2127086674A5035763329 @default.
- W2127086674 hasAuthorship W2127086674A5079128249 @default.
- W2127086674 hasConcept C105702510 @default.
- W2127086674 hasConcept C126322002 @default.
- W2127086674 hasConcept C141071460 @default.
- W2127086674 hasConcept C142724271 @default.
- W2127086674 hasConcept C204787440 @default.
- W2127086674 hasConcept C2776164576 @default.
- W2127086674 hasConcept C2777236700 @default.
- W2127086674 hasConcept C2779146052 @default.
- W2127086674 hasConcept C2780550940 @default.
- W2127086674 hasConcept C2781156865 @default.
- W2127086674 hasConcept C2908736133 @default.
- W2127086674 hasConcept C3018615303 @default.
- W2127086674 hasConcept C3020332539 @default.
- W2127086674 hasConcept C71924100 @default.
- W2127086674 hasConcept C96646087 @default.
- W2127086674 hasConceptScore W2127086674C105702510 @default.
- W2127086674 hasConceptScore W2127086674C126322002 @default.
- W2127086674 hasConceptScore W2127086674C141071460 @default.
- W2127086674 hasConceptScore W2127086674C142724271 @default.
- W2127086674 hasConceptScore W2127086674C204787440 @default.
- W2127086674 hasConceptScore W2127086674C2776164576 @default.
- W2127086674 hasConceptScore W2127086674C2777236700 @default.
- W2127086674 hasConceptScore W2127086674C2779146052 @default.
- W2127086674 hasConceptScore W2127086674C2780550940 @default.
- W2127086674 hasConceptScore W2127086674C2781156865 @default.
- W2127086674 hasConceptScore W2127086674C2908736133 @default.
- W2127086674 hasConceptScore W2127086674C3018615303 @default.
- W2127086674 hasConceptScore W2127086674C3020332539 @default.
- W2127086674 hasConceptScore W2127086674C71924100 @default.
- W2127086674 hasConceptScore W2127086674C96646087 @default.
- W2127086674 hasIssue "4" @default.
- W2127086674 hasLocation W21270866741 @default.
- W2127086674 hasOpenAccess W2127086674 @default.
- W2127086674 hasPrimaryLocation W21270866741 @default.
- W2127086674 hasRelatedWork W186008867 @default.
- W2127086674 hasRelatedWork W1934862209 @default.
- W2127086674 hasRelatedWork W1968820165 @default.
- W2127086674 hasRelatedWork W1970466275 @default.
- W2127086674 hasRelatedWork W1972518132 @default.
- W2127086674 hasRelatedWork W1973788415 @default.
- W2127086674 hasRelatedWork W1978552679 @default.
- W2127086674 hasRelatedWork W1993283705 @default.
- W2127086674 hasRelatedWork W1996381947 @default.
- W2127086674 hasRelatedWork W2008505221 @default.
- W2127086674 hasRelatedWork W2014587146 @default.
- W2127086674 hasRelatedWork W2016584233 @default.
- W2127086674 hasRelatedWork W2057509009 @default.
- W2127086674 hasRelatedWork W2067738795 @default.
- W2127086674 hasRelatedWork W2069526606 @default.
- W2127086674 hasRelatedWork W2070288401 @default.
- W2127086674 hasRelatedWork W2411535932 @default.
- W2127086674 hasRelatedWork W39616073 @default.
- W2127086674 hasRelatedWork W1787848125 @default.
- W2127086674 hasRelatedWork W44674334 @default.
- W2127086674 hasVolume "28" @default.
- W2127086674 isParatext "false" @default.
- W2127086674 isRetracted "false" @default.
- W2127086674 magId "2127086674" @default.
- W2127086674 workType "article" @default.