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• W2127093048 endingPage "209" @default.
• W2127093048 startingPage "209" @default.
• W2127093048 abstract "The U.S. Preventive Services Task Force (USPSTF) has not previously considered screening for hereditary hemochromatosis for a recommendation as a clinical preventive service for primary care clinicians.To conduct a focused systematic review of hereditary hemochromatosis screening relating to 2 USPSTF criteria, the burden of suffering and the potential effectiveness of a preventive intervention, to determine whether evidence is sufficient for a USPSTF recommendation.MEDLINE, CINAHL, and Cochrane Library databases from 1966 through February 2005. The authors supplemented literature searches with source materials from experts in the field and the bibliographies of key reviews and included studies.Studies were retrieved to answer 3 key questions: 1) What is the risk for developing clinical hemochromatosis among those with a homozygous C282Y genotype? 2) Does earlier therapeutic phlebotomy of individuals with primary iron overload due to hereditary hemochromatosis reduce morbidity and mortality compared with treatment after diagnosis in routine clinical care? 3) Are there groups at increased risk for developing hereditary hemochromatosis that can be readily identified before genetic screening? The authors critically appraised studies using quality criteria specific to their design.The authors abstracted all studies into evidence tables using condition definitions and diagnostic criteria.Data were insufficient to define a very precise estimate of penetrance. Available data suggest that up to 38% to 50% of C282Y homozygotes may develop iron overload, with up to 10% to 33% eventually developing hemochromatosis-associated morbidity. Prevalence of C282Y homozygosity is higher in family members of probands and other high-risk patient groups defined by signs, symptoms, and phenotypic screening.This review considered genetic screening for HFE-related hereditary hemochromatosis in C282Y homozygotes only. Available research is limited, is based solely on observational designs, and is plagued by poor or inconsistent reporting.Research addressing genetic screening for hereditary hemochromatosis remains insufficient to confidently project the impact of, or estimate the benefit from, widespread or high-risk genetic screening for hereditary hemochromatosis." @default.
• W2127093048 created "2016-06-24" @default.
• W2127093048 creator A5002540609 @default.
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• W2127093048 date "2006-08-01" @default.
• W2127093048 modified "2023-10-13" @default.
• W2127093048 title "Screening for Hereditary Hemochromatosis: A Systematic Review for the U.S. Preventive Services Task Force" @default.
• W2127093048 cites W127919598 @default.
• W2127093048 cites W1433466312 @default.
• W2127093048 cites W1498873432 @default.
• W2127093048 cites W150307755 @default.
• W2127093048 cites W1504843817 @default.
• W2127093048 cites W1505915776 @default.
• W2127093048 cites W1523009941 @default.
• W2127093048 cites W1542175259 @default.
• W2127093048 cites W1545507736 @default.
• W2127093048 cites W1567389668 @default.
• W2127093048 cites W1586695508 @default.
• W2127093048 cites W1588855012 @default.
• W2127093048 cites W1605353467 @default.
• W2127093048 cites W1627887482 @default.
• W2127093048 cites W163177553 @default.
• W2127093048 cites W1655170457 @default.
• W2127093048 cites W1697934388 @default.
• W2127093048 cites W1707907601 @default.
• W2127093048 cites W1752450468 @default.
• W2127093048 cites W1850319282 @default.
• W2127093048 cites W1862055694 @default.
• W2127093048 cites W1880301439 @default.
• W2127093048 cites W192714251 @default.
• W2127093048 cites W1966778627 @default.
• W2127093048 cites W1969589109 @default.
• W2127093048 cites W1970097714 @default.
• W2127093048 cites W1971241700 @default.
• W2127093048 cites W1972898360 @default.
• W2127093048 cites W1973979837 @default.
• W2127093048 cites W1974736288 @default.
• W2127093048 cites W1975215898 @default.
• W2127093048 cites W1975460915 @default.
• W2127093048 cites W1975695761 @default.
• W2127093048 cites W1978390018 @default.
• W2127093048 cites W1978766289 @default.
• W2127093048 cites W1978969178 @default.
• W2127093048 cites W1979446304 @default.
• W2127093048 cites W1979511836 @default.
• W2127093048 cites W1980310397 @default.
• W2127093048 cites W1980839077 @default.
• W2127093048 cites W1980846810 @default.
• W2127093048 cites W1982391510 @default.
• W2127093048 cites W1982574309 @default.
• W2127093048 cites W1985177555 @default.
• W2127093048 cites W1985533627 @default.
• W2127093048 cites W1985864332 @default.
• W2127093048 cites W1985888640 @default.
• W2127093048 cites W1986814496 @default.
• W2127093048 cites W1987057326 @default.
• W2127093048 cites W1987059062 @default.
• W2127093048 cites W1987250454 @default.
• W2127093048 cites W1988076017 @default.
• W2127093048 cites W1988664382 @default.
• W2127093048 cites W1988791340 @default.
• W2127093048 cites W1988990342 @default.
• W2127093048 cites W1989153941 @default.
• W2127093048 cites W1990362024 @default.
• W2127093048 cites W1990663225 @default.
• W2127093048 cites W1992013256 @default.
• W2127093048 cites W1992122879 @default.
• W2127093048 cites W1993899490 @default.
• W2127093048 cites W1994811917 @default.
• W2127093048 cites W1995403072 @default.
• W2127093048 cites W1995735496 @default.
• W2127093048 cites W1996393770 @default.
• W2127093048 cites W1997462858 @default.
• W2127093048 cites W1997532798 @default.
• W2127093048 cites W1997757761 @default.
• W2127093048 cites W1998583297 @default.
• W2127093048 cites W2000645323 @default.
• W2127093048 cites W2000789272 @default.
• W2127093048 cites W2001777392 @default.
• W2127093048 cites W2002605005 @default.
• W2127093048 cites W2002957252 @default.
• W2127093048 cites W2005620802 @default.
• W2127093048 cites W2008603627 @default.
• W2127093048 cites W2008818072 @default.
• W2127093048 cites W2011007951 @default.
• W2127093048 cites W2011813004 @default.
• W2127093048 cites W2011932646 @default.
• W2127093048 cites W2015287415 @default.
• W2127093048 cites W2015357027 @default.
• W2127093048 cites W2017207954 @default.
• W2127093048 cites W2017636464 @default.
• W2127093048 cites W2019168943 @default.
• W2127093048 cites W2020337134 @default.
• W2127093048 cites W2020800483 @default.
• W2127093048 cites W2021685891 @default.

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