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• W2127097046 abstract "Background: It was previously demonstrated that octreotide (Sandostatin) induced an increased apoptotic activity in human pancreatic cancer xenografts after a high dose, 1-month treatment. In the present study the effect of smaller doses (2x100 Ig/kg b.w.) administered in a short-term (4-day) experiment were investigated. Materials and Methods: CBA immunosuppressed mice bearing human pancreatic carcinoma (PXZ-40/6) were treated daily with 2x100 Ig/kg b.w. Sandostatin subcutaneously for 4 consecutive days. The number of tumor cells displaying apoptotic bodies (late event) and mitotic activity were assessed by morphometry, while the earlier phase of the apoptotic process was determined using flow cytometry. Results: A short octreotide treatment did not influence the mitotic activity, but the number of apoptotic cells decreased significantly (1.8±0.44/mm 2 in controls vs. 6.8±1.0/mm 2 in treated tumors, p<0.0009). The percentage of nuclei in sub-G1 phase almost doubled (6.0±0.75% in controls, 11.2±0.97% in the octreotide-treated group, p<0.0014). The DNA index and the proliferation indices proved to be unchanged. Conclusion: The results suggest that low doses of octreotide induce apoptosis in human pancreatic cancer xenografts after a short-term treatment. Somatostatin analogs (octreotide, lanreotide, vapreotide) are classically used for the treatment of acromegaly, carcinoid syndrome or gastro-entero-pancreatic neuroendocrine tumors. Their tumor-inhibiting effects are governed by complex direct and indirect mechanisms, including somatostatin receptor (SSTR)-mediated effects, antagonizing growth factor and hormone-release, regulating" @default.
• W2127097046 created "2016-06-24" @default.
• W2127097046 creator A5040162080 @default.
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• W2127097046 date "2006-07-01" @default.
• W2127097046 modified "2023-09-26" @default.
• W2127097046 title "Short-term octreotide treatment induces apoptosis in human pancreatic cancer xenografts." @default.
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• W2127097046 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16900788" @default.
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