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• W2127116120 abstract "Amphotericin B delays the onset of clinical symptoms in hamsters infected with scrapie agent strain 263K. Here we show that accumulation of a scrapie-specific isoform of the prion protein (PrP-res) and agent replication were delayed early in amphotericin B-treated animals. By 8 weeks postinfection, only untreated animals exhibited clinical symptoms of scrapie infection whereas PrP-res levels and titers were similar in treated and untreated animals. This suggests that although PrP-res accumulation and agent replication are linked, they are not the sole factors required for the onset of clinical disease." @default.
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• W2127116120 date "1994-11-01" @default.
• W2127116120 modified "2023-10-16" @default.
• W2127116120 title "Amphotericin B delays both scrapie agent replication and PrP-res accumulation early in infection" @default.
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• W2127116120 doi "https://doi.org/10.1128/jvi.68.11.7534-7536.1994" @default.
• W2127116120 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/237196" @default.
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