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• W2127119276 abstract "Background: Studies in adults with major depressive disorder (MDD) document abnormalities in both memory and face‐emotion processing. The current study used a novel face‐memory task to test the hypothesis that adolescent MDD is associated with a deficit in memory for face‐emotions. The study also examines the relationship between parental MDD and memory performance in offspring. Methods: Subjects were 152 offspring (ages 9–19) of adults with either MDD, anxiety disorders, both MDD and anxiety, or no disorder. Parents and offspring were assessed for mental disorders. Collection of face‐memory data was blind to offspring and parent diagnosis. A computerized task was developed that required rating of facial photographs depicting ‘happy,’‘fearful,’ or ‘angry’ emotions followed by a memory recall test. Recall accuracy was examined as a function of face‐emotion type. Results: Age and gender independently predicted memory, with better recall in older and female subjects. Controlling for age and gender, offspring with a history of MDD ( n = 19) demonstrated significant deficits in memory selectively for fearful faces, but not happy or angry faces. Parental MDD was not associated with face‐memory accuracy. Discussion: This study found an association between MDD in childhood or adolescence and perturbed encoding of fearful faces. MDD in young individuals may predispose to subtle anomalies in a neural circuit encompassing the amygdala, a brain region implicated in the processing of fearful facial expressions. These findings suggest that brain imaging studies using similar face‐emotion paradigms should test whether deficits in processing of fearful faces relate to amygdala dysfunction in children and adolescents with MDD." @default.
• W2127119276 created "2016-06-24" @default.
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• W2127119276 date "2004-08-27" @default.
• W2127119276 modified "2023-10-11" @default.
• W2127119276 title "Face-memory and emotion: associations with major depression in children and adolescents" @default.
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• W2127119276 doi "https://doi.org/10.1111/j.1469-7610.2004.00311.x" @default.
• W2127119276 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15335340" @default.
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