FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2127123729> ?p ?o ?g. }

• W2127123729 endingPage "1111" @default.
• W2127123729 startingPage "1106" @default.
• W2127123729 abstract "Strategies to promote angiogenesis can benefit cerebral ischemia. We determined whether liposomal delivery of angiogenic peptides with a known biologic activity of vascular endothelial growth factor benefitted cerebral ischemia. Also, the study examined the potential of (18)F-FDG PET imaging in ischemic stroke treatment.Male Sprague-Dawley rats (n = 40) underwent 40 min of middle cerebral artery occlusion. After 15 min of reperfusion, the rats (n = 10) received angiogenic peptides incorporated into liposomes. Animals receiving phosphate-buffered solution or liposomes without peptides served as controls. One week later, (18)F-FDG PET imaging was performed to examine regional changes in glucose utilization in response to the angiogenic therapy. The following day, (99m)Tc-hexamethylpropyleneamine oxime autoradiography was performed to determine changes in cerebral perfusion after angiogenic therapy. Corresponding changes in angiogenic markers, including von Willebrand factor and angiopoietin-1 and -2, were determined by immunostaining and polymerase chain reaction analysis, respectively.A 40-min period of middle cerebral artery occlusion decreased blood perfusion in the ipsilateral ischemic cortex of the brain, compared with that in the contralateral cortex, as measured by (99m)Tc-hexamethylpropyleneamine oxime autoradiography. Liposomal delivery of angiogenic peptides to the ischemic hemisphere of the brain attenuated the cerebral perfusion defect compared with controls. Similarly, vascular density evidenced by von Willebrand factor-positive staining was increased in response to angiogenic therapy, compared with that of controls. This increase was accompanied by an early increase in angiopoietin-2 expression, a gene participating in angiogenesis. (18)F-FDG PET imaging measured at 7 d after treatment revealed that liposomal delivery of angiogenic peptides facilitated glucose utilization in the ipsilateral ischemic cortex of the brain, compared with that in the controls. Furthermore, the change in regional glucose utilization was correlated with the extent of improvement in cerebral perfusion (r = 0.742, P = 0.035).Liposomal delivery of angiogenic peptides benefits cerebral ischemia. (18)F-FDG PET imaging holds promise as an indicator of the effectiveness of angiogenic therapy in cerebral ischemia." @default.
• W2127123729 created "2016-06-24" @default.
• W2127123729 creator A5011091703 @default.
• W2127123729 creator A5020734351 @default.
• W2127123729 creator A5022462467 @default.
• W2127123729 creator A5027473085 @default.
• W2127123729 creator A5064204310 @default.
• W2127123729 creator A5073684286 @default.
• W2127123729 creator A5074421507 @default.
• W2127123729 date "2015-05-14" @default.
• W2127123729 modified "2023-09-23" @default.
• W2127123729 title "Improving Cerebral Blood Flow Through Liposomal Delivery of Angiogenic Peptides: Potential of ¹⁸F-FDG PET Imaging in Ischemic Stroke Treatment" @default.
• W2127123729 cites W1524572279 @default.
• W2127123729 cites W1970088949 @default.
• W2127123729 cites W1977418950 @default.
• W2127123729 cites W1987570599 @default.
• W2127123729 cites W2006767153 @default.
• W2127123729 cites W2014764992 @default.
• W2127123729 cites W2028991092 @default.
• W2127123729 cites W2038809383 @default.
• W2127123729 cites W2040613213 @default.
• W2127123729 cites W2042448451 @default.
• W2127123729 cites W2051206394 @default.
• W2127123729 cites W2059998669 @default.
• W2127123729 cites W2077489685 @default.
• W2127123729 cites W2081510823 @default.
• W2127123729 cites W2085362322 @default.
• W2127123729 cites W2096483916 @default.
• W2127123729 cites W2105536017 @default.
• W2127123729 cites W2119562338 @default.
• W2127123729 cites W2129282529 @default.
• W2127123729 cites W2141395957 @default.
• W2127123729 cites W4254041558 @default.
• W2127123729 cites W4254868516 @default.
• W2127123729 doi "https://doi.org/10.2967/jnumed.115.154443" @default.
• W2127123729 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25977466" @default.
• W2127123729 hasPublicationYear "2015" @default.
• W2127123729 type Work @default.
• W2127123729 sameAs 2127123729 @default.
• W2127123729 citedByCount "25" @default.
• W2127123729 countsByYear W21271237292016 @default.
• W2127123729 countsByYear W21271237292017 @default.
• W2127123729 countsByYear W21271237292018 @default.
• W2127123729 countsByYear W21271237292019 @default.
• W2127123729 countsByYear W21271237292020 @default.
• W2127123729 countsByYear W21271237292021 @default.
• W2127123729 countsByYear W21271237292022 @default.
• W2127123729 countsByYear W21271237292023 @default.
• W2127123729 crossrefType "journal-article" @default.
• W2127123729 hasAuthorship W2127123729A5011091703 @default.
• W2127123729 hasAuthorship W2127123729A5020734351 @default.
• W2127123729 hasAuthorship W2127123729A5022462467 @default.
• W2127123729 hasAuthorship W2127123729A5027473085 @default.
• W2127123729 hasAuthorship W2127123729A5064204310 @default.
• W2127123729 hasAuthorship W2127123729A5073684286 @default.
• W2127123729 hasAuthorship W2127123729A5074421507 @default.
• W2127123729 hasBestOaLocation W21271237291 @default.
• W2127123729 hasConcept C126322002 @default.
• W2127123729 hasConcept C127413603 @default.
• W2127123729 hasConcept C135691158 @default.
• W2127123729 hasConcept C142724271 @default.
• W2127123729 hasConcept C146957229 @default.
• W2127123729 hasConcept C157767197 @default.
• W2127123729 hasConcept C167734588 @default.
• W2127123729 hasConcept C204232928 @default.
• W2127123729 hasConcept C2777025900 @default.
• W2127123729 hasConcept C2778271429 @default.
• W2127123729 hasConcept C2779394231 @default.
• W2127123729 hasConcept C2780394083 @default.
• W2127123729 hasConcept C2780645631 @default.
• W2127123729 hasConcept C2781188250 @default.
• W2127123729 hasConcept C4224716 @default.
• W2127123729 hasConcept C541997718 @default.
• W2127123729 hasConcept C71924100 @default.
• W2127123729 hasConcept C78519656 @default.
• W2127123729 hasConcept C89560881 @default.
• W2127123729 hasConceptScore W2127123729C126322002 @default.
• W2127123729 hasConceptScore W2127123729C127413603 @default.
• W2127123729 hasConceptScore W2127123729C135691158 @default.
• W2127123729 hasConceptScore W2127123729C142724271 @default.
• W2127123729 hasConceptScore W2127123729C146957229 @default.
• W2127123729 hasConceptScore W2127123729C157767197 @default.
• W2127123729 hasConceptScore W2127123729C167734588 @default.
• W2127123729 hasConceptScore W2127123729C204232928 @default.
• W2127123729 hasConceptScore W2127123729C2777025900 @default.
• W2127123729 hasConceptScore W2127123729C2778271429 @default.
• W2127123729 hasConceptScore W2127123729C2779394231 @default.
• W2127123729 hasConceptScore W2127123729C2780394083 @default.
• W2127123729 hasConceptScore W2127123729C2780645631 @default.
• W2127123729 hasConceptScore W2127123729C2781188250 @default.
• W2127123729 hasConceptScore W2127123729C4224716 @default.
• W2127123729 hasConceptScore W2127123729C541997718 @default.
• W2127123729 hasConceptScore W2127123729C71924100 @default.
• W2127123729 hasConceptScore W2127123729C78519656 @default.
• W2127123729 hasConceptScore W2127123729C89560881 @default.
• W2127123729 hasIssue "7" @default.
• W2127123729 hasLocation W21271237291 @default.
• W2127123729 hasLocation W21271237292 @default.

• next