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- W2127149431 abstract "At least 12 virus-induced DNA-binding proteins with mol. wt. ranging from 14 X 10(3) have been isolated from frog virus (FV 3)-infected fathead minnow cells by DNA affinity chromatography. Two enzymic activities, DNA-dependent DNA polymerase and endodeoxyribonuclease, were present in the DNA-binding proteins; these enzymic activities were similar to those induced by FV 3 in infected cells. A single species of DNA-binding proteins with a mol. wt of 36 000 had very high affinity for single-stranded DNA, but a low one for double-stranded DNA. Proteins with such characteristic affinity for single-stranded DNA destabilize the DNA helix and are essential for viral DNA replication. Thus, the 36 000 mol. wt. DNA-binding protein is a candidate for such a role in FV 3 DNA replication." @default.
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- W2127149431 date "1981-09-01" @default.
- W2127149431 modified "2023-09-25" @default.
- W2127149431 title "DNA-binding Proteins in Frog Virus 3-infected Cells" @default.
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- W2127149431 doi "https://doi.org/10.1099/0022-1317-56-1-131" @default.
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