FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2127156717> ?p ?o ?g. }

• W2127156717 endingPage "1853" @default.
• W2127156717 startingPage "1843" @default.
• W2127156717 abstract "The human circadian system is known to affect the pharmacokinetics and pharmacodynamics of several classes of respiratory disease medications. The current study involving 16 healthy adults investigated if the time-of-day of dosing of roflumilast, a novel phosphodiesterase-4 inhibitor, affects its pharmacokinetics. The rate of drug absorption (tmax: 1.50 versus 2.00 h) and peak concentration at tmax (Cmax: 3.79 versus 3.06 µg/L) was slightly greater with morning than evening administration, but without clinical significance. The extent of drug absorption (AUC) and drug elimination (t1/2) did not differ between the two dosing times. The pharmacokinetics of the active main metabolite, roflumilast N-oxide, also was not affected by the time of drug administration. Finally, the safety and tolerability of roflumilast did not differ between the two different times of administration. (E-mail correspondence: thomas.bethke@nycomed.com)" @default.
• W2127156717 created "2016-06-24" @default.
• W2127156717 creator A5014868745 @default.
• W2127156717 creator A5068537404 @default.
• W2127156717 creator A5072521472 @default.
• W2127156717 creator A5091479053 @default.
• W2127156717 date "2010-10-25" @default.
• W2127156717 modified "2023-09-23" @default.
• W2127156717 title "CHRONOPHARMACOLOGY OF ROFLUMILAST: A COMPARATIVE PHARMACOKINETIC STUDY OF MORNING VERSUS EVENING ADMINISTRATION IN HEALTHY ADULTS" @default.
• W2127156717 cites W1472243025 @default.
• W2127156717 cites W1963871753 @default.
• W2127156717 cites W1966630256 @default.
• W2127156717 cites W1971448764 @default.
• W2127156717 cites W1980944107 @default.
• W2127156717 cites W1989325705 @default.
• W2127156717 cites W2016092648 @default.
• W2127156717 cites W2020986585 @default.
• W2127156717 cites W2030458665 @default.
• W2127156717 cites W2036471103 @default.
• W2127156717 cites W2037698344 @default.
• W2127156717 cites W2042446689 @default.
• W2127156717 cites W2043435287 @default.
• W2127156717 cites W2047295650 @default.
• W2127156717 cites W2061995737 @default.
• W2127156717 cites W2073802634 @default.
• W2127156717 cites W2081299047 @default.
• W2127156717 cites W2086812070 @default.
• W2127156717 cites W2096189541 @default.
• W2127156717 cites W2097243317 @default.
• W2127156717 cites W2098761057 @default.
• W2127156717 cites W2107107374 @default.
• W2127156717 cites W2108389895 @default.
• W2127156717 cites W2117301219 @default.
• W2127156717 cites W2143845055 @default.
• W2127156717 cites W2150971973 @default.
• W2127156717 cites W2167426831 @default.
• W2127156717 cites W2324080285 @default.
• W2127156717 doi "https://doi.org/10.3109/07420528.2010.520398" @default.
• W2127156717 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20969527" @default.
• W2127156717 hasPublicationYear "2010" @default.
• W2127156717 type Work @default.
• W2127156717 sameAs 2127156717 @default.
• W2127156717 citedByCount "6" @default.
• W2127156717 countsByYear W21271567172013 @default.
• W2127156717 countsByYear W21271567172015 @default.
• W2127156717 countsByYear W21271567172020 @default.
• W2127156717 crossrefType "journal-article" @default.
• W2127156717 hasAuthorship W2127156717A5014868745 @default.
• W2127156717 hasAuthorship W2127156717A5068537404 @default.
• W2127156717 hasAuthorship W2127156717A5072521472 @default.
• W2127156717 hasAuthorship W2127156717A5091479053 @default.
• W2127156717 hasConcept C111113717 @default.
• W2127156717 hasConcept C112705442 @default.
• W2127156717 hasConcept C121332964 @default.
• W2127156717 hasConcept C126322002 @default.
• W2127156717 hasConcept C1276947 @default.
• W2127156717 hasConcept C149151106 @default.
• W2127156717 hasConcept C181389837 @default.
• W2127156717 hasConcept C19720800 @default.
• W2127156717 hasConcept C197934379 @default.
• W2127156717 hasConcept C22979827 @default.
• W2127156717 hasConcept C2776476923 @default.
• W2127156717 hasConcept C2776780178 @default.
• W2127156717 hasConcept C2777056448 @default.
• W2127156717 hasConcept C2777288759 @default.
• W2127156717 hasConcept C2778375690 @default.
• W2127156717 hasConcept C2778926808 @default.
• W2127156717 hasConcept C71924100 @default.
• W2127156717 hasConcept C98274493 @default.
• W2127156717 hasConceptScore W2127156717C111113717 @default.
• W2127156717 hasConceptScore W2127156717C112705442 @default.
• W2127156717 hasConceptScore W2127156717C121332964 @default.
• W2127156717 hasConceptScore W2127156717C126322002 @default.
• W2127156717 hasConceptScore W2127156717C1276947 @default.
• W2127156717 hasConceptScore W2127156717C149151106 @default.
• W2127156717 hasConceptScore W2127156717C181389837 @default.
• W2127156717 hasConceptScore W2127156717C19720800 @default.
• W2127156717 hasConceptScore W2127156717C197934379 @default.
• W2127156717 hasConceptScore W2127156717C22979827 @default.
• W2127156717 hasConceptScore W2127156717C2776476923 @default.
• W2127156717 hasConceptScore W2127156717C2776780178 @default.
• W2127156717 hasConceptScore W2127156717C2777056448 @default.
• W2127156717 hasConceptScore W2127156717C2777288759 @default.
• W2127156717 hasConceptScore W2127156717C2778375690 @default.
• W2127156717 hasConceptScore W2127156717C2778926808 @default.
• W2127156717 hasConceptScore W2127156717C71924100 @default.
• W2127156717 hasConceptScore W2127156717C98274493 @default.
• W2127156717 hasIssue "9-10" @default.
• W2127156717 hasLocation W21271567171 @default.
• W2127156717 hasLocation W21271567172 @default.
• W2127156717 hasOpenAccess W2127156717 @default.
• W2127156717 hasPrimaryLocation W21271567171 @default.
• W2127156717 hasRelatedWork W2004325424 @default.
• W2127156717 hasRelatedWork W2008184149 @default.
• W2127156717 hasRelatedWork W2040224589 @default.
• W2127156717 hasRelatedWork W2056938528 @default.
• W2127156717 hasRelatedWork W2331297863 @default.
• W2127156717 hasRelatedWork W2389679993 @default.

• next