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- W2127157268 abstract "The nonmevalonate pathway (NMP) of isoprene biosynthesis is an exciting new route toward novel antibiotic development. Inhibitors against several enzymes in this pathway are currently under examination. A significant liability of many of these agents is poor cell penetration. To overcome and improve our understanding of this problem, we have synthesized a series of lipophilic, prodrug analogs of fosmidomycin and FR900098, inhibitors of the NMP enzyme Dxr. Several of these compounds show improved antibacterial activity against a panel of organisms relative to the parent compound, including activity against Mycobacterium tuberculosis (Mtb). Our results show that this strategy can be an effective way for improving whole cell activity of NMP inhibitors." @default.
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- W2127157268 date "2011-12-01" @default.
- W2127157268 modified "2023-09-29" @default.
- W2127157268 title "Antibacterial and antitubercular activity of fosmidomycin, FR900098, and their lipophilic analogs" @default.
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- W2127157268 doi "https://doi.org/10.1016/j.bmcl.2011.09.123" @default.
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