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• W2127181037 abstract "Background: Atrial thrombus formation in patients with atrial flutter raises concerns ofstroke risk. We investigated patients with isthmus-dependent atrial flutter for coagulationabnormalities before and after cardioversion to sinus rhythm by catheter ablation, and evaluatedthe relationship of the abnormalities to the echocardiographic risk markers of stroke. Methods and results: Plasma samples were drawn prior to insertion of catheters, immediatelyafter the procedure, and 24 hours afterwards. At baseline, coagulation abnormalitieswere found in 22 out of 25 patients (88%). von Willebrand factor antigen (vWF-Ag) and factorVIII:C were elevated in 17 patients (68%) and 15 patients (60%), respectively. At baseline,mean plasma levels of vWF-Ag (250.1 ± 144.4%) and factor VIII:C (215.0 ± 77.1%) wereincreased. Key markers of thrombin generation, thrombin-antithrombin III complex (TAT;47.8 ± 30.9 μg/L vs 14.5 ± 13.8 μg/L; p vs 1.2 ± 1.0 nmoL/L) were significantly elevated in the presence ofspontaneous echo contrast. Further, both markers of thrombin generation inversely correlatedwith left atrial appendage emptying velocity (r = -0.42 and -0.63, p Conclusions: Endothelial-dependent coagulation factors were enhanced in most patientswith atrial flutter. Spontaneous echo contrast and decreased atrial contractility were associatedwith increased thrombin generation. After conversion and ablation, an increase in thrombingeneration and fibrinolysis suggest a transient pro-thrombotic state. (Cardiol J 2010; 17, 4: 390-396)" @default.
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• W2127181037 date "2010-01-01" @default.
• W2127181037 modified "2023-09-27" @default.
• W2127181037 title "Activation of the endogenous coagulation system in patients with atrial flutter: Relationship to echocardiographic markers of thromboembolic risk" @default.
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