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- W2127187639 abstract "Autophagy, a homeostatic process whereby eukaryotic cells target cytoplasmic cargo for degradation, plays a broad role in health and disease states. Here we screened the TRIM family for roles in autophagy and found that half of TRIMs modulated autophagy. In mechanistic studies, we show that TRIMs associate with autophagy factors and act as platforms assembling ULK1 and Beclin 1 in their activated states. Furthermore, TRIM5α acts as a selective autophagy receptor. Based on direct sequence-specific recognition, TRIM5α delivered its cognate cytosolic target, a viral capsid protein, for autophagic degradation. Thus, our study establishes that TRIMs can function both as regulators of autophagy and as autophagic cargo receptors, and reveals a basis for selective autophagy in mammalian cells." @default.
- W2127187639 created "2016-06-24" @default.
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- W2127187639 date "2014-08-01" @default.
- W2127187639 modified "2023-10-10" @default.
- W2127187639 title "TRIM Proteins Regulate Autophagy and Can Target Autophagic Substrates by Direct Recognition" @default.
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- W2127187639 doi "https://doi.org/10.1016/j.devcel.2014.06.013" @default.
- W2127187639 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4146662" @default.
- W2127187639 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25127057" @default.
- W2127187639 hasPublicationYear "2014" @default.
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