FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2127190523> ?p ?o ?g. }

• W2127190523 endingPage "1320" @default.
• W2127190523 startingPage "1311" @default.
• W2127190523 abstract "Acute inflammation is a common feature of many life-threatening pathologies, including septic shock. One hallmark of acute inflammation is the peroxidation of polyunsaturated fatty acids forming bioactive products that regulate inflammation. Myeloperoxidase (MPO) is an abundant phagocyte-derived hemoprotein released during phagocyte activation. Here, we investigated the role of MPO in modulating biologically active arachidonic acid (AA) and linoleic acid (LA) metabolites during acute inflammation. Wild-type and MPO-knockout (KO) mice were exposed to intraperitoneally injected endotoxin for 24 h, and plasma LA and AA oxidation products were comprehensively analyzed using a liquid chromatography–mass spectrometry method. Compared to wild-type mice, MPO-KO mice had significantly lower plasma levels of LA epoxides and corresponding LA- and AA-derived fatty acid diols. AA and LA hydroxy intermediates (hydroxyeicosatetraenoic and hydroxyoctadecadienoic acids) were also significantly lower in MPO-KO mice. Conversely, MPO-deficient mice had significantly higher plasma levels of cysteinyl-leukotrienes with well-known proinflammatory properties. In vitro experiments revealed significantly lower amounts of AA and LA epoxides, LA- and AA-derived fatty acid diols, and AA and LA hydroxy intermediates in stimulated polymorphonuclear neutrophils isolated from MPO-KO mice. Our results demonstrate that MPO modulates the balance of pro- and anti-inflammatory lipid mediators during acute inflammation and, in this way, may control acute inflammatory diseases." @default.
• W2127190523 created "2016-06-24" @default.
• W2127190523 creator A5005316763 @default.
• W2127190523 creator A5026538320 @default.
• W2127190523 creator A5036647062 @default.
• W2127190523 creator A5049514965 @default.
• W2127190523 creator A5053048440 @default.
• W2127190523 creator A5053307676 @default.
• W2127190523 creator A5054124191 @default.
• W2127190523 date "2010-05-15" @default.
• W2127190523 modified "2023-10-13" @default.
• W2127190523 title "Modulation of arachidonic and linoleic acid metabolites in myeloperoxidase-deficient mice during acute inflammation" @default.
• W2127190523 cites W1505976169 @default.
• W2127190523 cites W1559121852 @default.
• W2127190523 cites W1561615847 @default.
• W2127190523 cites W1588042372 @default.
• W2127190523 cites W1602460865 @default.
• W2127190523 cites W1644991946 @default.
• W2127190523 cites W1821971821 @default.
• W2127190523 cites W1963750002 @default.
• W2127190523 cites W1966576495 @default.
• W2127190523 cites W1977922788 @default.
• W2127190523 cites W1979229962 @default.
• W2127190523 cites W1981594250 @default.
• W2127190523 cites W1987124995 @default.
• W2127190523 cites W1989409713 @default.
• W2127190523 cites W1993788673 @default.
• W2127190523 cites W2003110293 @default.
• W2127190523 cites W2006479775 @default.
• W2127190523 cites W2012961732 @default.
• W2127190523 cites W2018319340 @default.
• W2127190523 cites W2019140140 @default.
• W2127190523 cites W2021509182 @default.
• W2127190523 cites W2022197180 @default.
• W2127190523 cites W2025694904 @default.
• W2127190523 cites W2026228990 @default.
• W2127190523 cites W2037258934 @default.
• W2127190523 cites W2040815828 @default.
• W2127190523 cites W2043304786 @default.
• W2127190523 cites W2043446682 @default.
• W2127190523 cites W2043756056 @default.
• W2127190523 cites W2049670948 @default.
• W2127190523 cites W2051311394 @default.
• W2127190523 cites W2059149560 @default.
• W2127190523 cites W2061837477 @default.
• W2127190523 cites W2062282839 @default.
• W2127190523 cites W2065435894 @default.
• W2127190523 cites W2065721609 @default.
• W2127190523 cites W2067674980 @default.
• W2127190523 cites W2074389951 @default.
• W2127190523 cites W2082548541 @default.
• W2127190523 cites W2090369846 @default.
• W2127190523 cites W2100890992 @default.
• W2127190523 cites W2107020991 @default.
• W2127190523 cites W2109539718 @default.
• W2127190523 cites W2110043655 @default.
• W2127190523 cites W2111204258 @default.
• W2127190523 cites W2116378084 @default.
• W2127190523 cites W2116835524 @default.
• W2127190523 cites W2119429228 @default.
• W2127190523 cites W2121811672 @default.
• W2127190523 cites W2125605952 @default.
• W2127190523 cites W2132899427 @default.
• W2127190523 cites W2133536720 @default.
• W2127190523 cites W2137623306 @default.
• W2127190523 cites W2162810062 @default.
• W2127190523 cites W2168897708 @default.
• W2127190523 cites W2179092050 @default.
• W2127190523 cites W2227330351 @default.
• W2127190523 cites W2277613935 @default.
• W2127190523 cites W2461077338 @default.
• W2127190523 doi "https://doi.org/10.1016/j.freeradbiomed.2010.02.010" @default.
• W2127190523 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2856720" @default.
• W2127190523 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20156554" @default.
• W2127190523 hasPublicationYear "2010" @default.
• W2127190523 type Work @default.
• W2127190523 sameAs 2127190523 @default.
• W2127190523 citedByCount "34" @default.
• W2127190523 countsByYear W21271905232012 @default.
• W2127190523 countsByYear W21271905232013 @default.
• W2127190523 countsByYear W21271905232014 @default.
• W2127190523 countsByYear W21271905232015 @default.
• W2127190523 countsByYear W21271905232016 @default.
• W2127190523 countsByYear W21271905232017 @default.
• W2127190523 countsByYear W21271905232018 @default.
• W2127190523 countsByYear W21271905232019 @default.
• W2127190523 countsByYear W21271905232020 @default.
• W2127190523 countsByYear W21271905232021 @default.
• W2127190523 countsByYear W21271905232022 @default.
• W2127190523 countsByYear W21271905232023 @default.
• W2127190523 crossrefType "journal-article" @default.
• W2127190523 hasAuthorship W2127190523A5005316763 @default.
• W2127190523 hasAuthorship W2127190523A5026538320 @default.
• W2127190523 hasAuthorship W2127190523A5036647062 @default.
• W2127190523 hasAuthorship W2127190523A5049514965 @default.
• W2127190523 hasAuthorship W2127190523A5053048440 @default.
• W2127190523 hasAuthorship W2127190523A5053307676 @default.
• W2127190523 hasAuthorship W2127190523A5054124191 @default.

• next