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- W2127198001 abstract "ABSTRACT The medicinal value associated with complex polyketide and nonribosomal peptide natural products has prompted biosynthetic schemes dependent upon heterologous microbial hosts. Here we report the successful biosynthesis of yersiniabactin (Ybt), a model polyketide-nonribosomal peptide hybrid natural product, using Escherichia coli as a heterologous host. After introducing the biochemical pathway for Ybt into E. coli , biosynthesis was initially monitored qualitatively by mass spectrometry. Next, production of Ybt was quantified in a high-cell-density fermentation environment with titers reaching 67 ± 21 (mean ± standard deviation) mg/liter and a volumetric productivity of 1.1 ± 0.3 mg/liter-h. This success has implications for basic and applied studies on Ybt biosynthesis and also, more generally, for future production of polyketide, nonribosomal peptide, and mixed polyketide-nonribosomal peptide natural products using E. coli ." @default.
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- W2127198001 date "2003-11-01" @default.
- W2127198001 modified "2023-10-10" @default.
- W2127198001 title "Biosynthesis of Yersiniabactin, a Complex Polyketide-Nonribosomal Peptide, Using <i>Escherichia coli</i> as a Heterologous Host" @default.
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- W2127198001 doi "https://doi.org/10.1128/aem.69.11.6698-6702.2003" @default.
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