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- W2127202275 abstract "FoxH1 (FAST) is a transcription factor that mediates signaling by transforming growth factor–β, Activin, and Nodal. The role of FoxH1 in development has now been investigated by the generation and analysis of FoxH1-deficient ( FoxH1 −/− ) mice. The FoxH1 −/− embryos showed various patterning defects that recapitulate most of the defects induced by the loss of Nodal signaling. A substantial proportion of FoxH1 −/− embryos failed to orient the anterior-posterior (A-P) axis correctly, as do mice lacking Cripto, a coreceptor for Nodal. In less severely affected FoxH1 −/− embryos, A-P polarity was established, but the primitive streak failed to elongate, resulting in the lack of a definitive node and its derivatives. Heterozygosity for nodal renders the FoxH1 −/− phenotype more severe, indicative of a genetic interaction between FoxH1 and nodal . The expression of FoxH1 in the primitive endoderm rescued the A-P patterning defects, but not the midline defects, of FoxH1 −/− mice. These results indicate that a Nodal-FoxH1 signaling pathway plays a central role in A-P patterning and node formation in the mouse." @default.
- W2127202275 created "2016-06-24" @default.
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- W2127202275 date "2001-05-15" @default.
- W2127202275 modified "2023-10-15" @default.
- W2127202275 title "The transcription factor FoxH1 (FAST) mediates Nodal signaling during anterior-posterior patterning and node formation in the mouse" @default.
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- W2127202275 doi "https://doi.org/10.1101/gad.883901" @default.
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