Matches in SemOpenAlex for { <https://semopenalex.org/work/W2127214059> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2127214059 abstract "Glutathione S-transferase (GST) enzymes play a role in detoxification of several carcinogens. Inherited absence of both alleles are common in human in two subtypes of GST gene superfamily, -M1 and -T1, by varying frequencies among different populations. The absence of both alleles result in loss of enzymatic activity and are related to increased risk for development of various cancer types. In this study, we investigated the association of GSTM1 and GSTT1 genetic profiles with clinicopathological parameters in prostate cancer. GSTM1 and GSTT1 genotypes were assessed by multiplex PCR and high resolution melting curve analysis method in 162 patients that underwent radical prostatectomy for localised prostate cancer. Their association with prognostic parameters were analysed. Frequencies of GSTM1 null and GSTT1 null genotypes were 82/162 (50.6%) and 33/162 (20.4%), respectively. No any significant differences were observed between different genotype groups and clinicopathological parameters including Gleason score, pathological stage, tumor volume, surgical margin status, extraprostatic extension, seminal vesicle invasion, perineural invasion or patient age. Although the roles of GSTM1 and GSTT1 deletions on prostate cancer risk was indicated in Turkish population, our results revealed that null or wild type genotypes of GSTM1 and GSTT1 genes are not associated with prognostic parameters in prostate cancer." @default.
- W2127214059 created "2016-06-24" @default.
- W2127214059 creator A5011176069 @default.
- W2127214059 creator A5011830171 @default.
- W2127214059 creator A5021112716 @default.
- W2127214059 creator A5029369658 @default.
- W2127214059 creator A5034150216 @default.
- W2127214059 creator A5059022288 @default.
- W2127214059 date "2014-01-01" @default.
- W2127214059 modified "2023-10-08" @default.
- W2127214059 title "Lack of association between glutathione S-transferase -M1 and -T1 gene polymorphisms with clinicopathological parameters in prostate cancer" @default.
- W2127214059 doi "https://doi.org/10.5455/dmm.20140420063016" @default.
- W2127214059 hasPublicationYear "2014" @default.
- W2127214059 type Work @default.
- W2127214059 sameAs 2127214059 @default.
- W2127214059 citedByCount "0" @default.
- W2127214059 crossrefType "journal-article" @default.
- W2127214059 hasAuthorship W2127214059A5011176069 @default.
- W2127214059 hasAuthorship W2127214059A5011830171 @default.
- W2127214059 hasAuthorship W2127214059A5021112716 @default.
- W2127214059 hasAuthorship W2127214059A5029369658 @default.
- W2127214059 hasAuthorship W2127214059A5034150216 @default.
- W2127214059 hasAuthorship W2127214059A5059022288 @default.
- W2127214059 hasBestOaLocation W21272140591 @default.
- W2127214059 hasConcept C104317684 @default.
- W2127214059 hasConcept C121608353 @default.
- W2127214059 hasConcept C126322002 @default.
- W2127214059 hasConcept C135763542 @default.
- W2127214059 hasConcept C142724271 @default.
- W2127214059 hasConcept C143998085 @default.
- W2127214059 hasConcept C180754005 @default.
- W2127214059 hasConcept C181199279 @default.
- W2127214059 hasConcept C2776235491 @default.
- W2127214059 hasConcept C2776907368 @default.
- W2127214059 hasConcept C2777154038 @default.
- W2127214059 hasConcept C2780122483 @default.
- W2127214059 hasConcept C2780192828 @default.
- W2127214059 hasConcept C2908647359 @default.
- W2127214059 hasConcept C502942594 @default.
- W2127214059 hasConcept C538909803 @default.
- W2127214059 hasConcept C54355233 @default.
- W2127214059 hasConcept C55493867 @default.
- W2127214059 hasConcept C71924100 @default.
- W2127214059 hasConcept C86803240 @default.
- W2127214059 hasConcept C99454951 @default.
- W2127214059 hasConceptScore W2127214059C104317684 @default.
- W2127214059 hasConceptScore W2127214059C121608353 @default.
- W2127214059 hasConceptScore W2127214059C126322002 @default.
- W2127214059 hasConceptScore W2127214059C135763542 @default.
- W2127214059 hasConceptScore W2127214059C142724271 @default.
- W2127214059 hasConceptScore W2127214059C143998085 @default.
- W2127214059 hasConceptScore W2127214059C180754005 @default.
- W2127214059 hasConceptScore W2127214059C181199279 @default.
- W2127214059 hasConceptScore W2127214059C2776235491 @default.
- W2127214059 hasConceptScore W2127214059C2776907368 @default.
- W2127214059 hasConceptScore W2127214059C2777154038 @default.
- W2127214059 hasConceptScore W2127214059C2780122483 @default.
- W2127214059 hasConceptScore W2127214059C2780192828 @default.
- W2127214059 hasConceptScore W2127214059C2908647359 @default.
- W2127214059 hasConceptScore W2127214059C502942594 @default.
- W2127214059 hasConceptScore W2127214059C538909803 @default.
- W2127214059 hasConceptScore W2127214059C54355233 @default.
- W2127214059 hasConceptScore W2127214059C55493867 @default.
- W2127214059 hasConceptScore W2127214059C71924100 @default.
- W2127214059 hasConceptScore W2127214059C86803240 @default.
- W2127214059 hasConceptScore W2127214059C99454951 @default.
- W2127214059 hasLocation W21272140591 @default.
- W2127214059 hasOpenAccess W2127214059 @default.
- W2127214059 hasPrimaryLocation W21272140591 @default.
- W2127214059 hasRelatedWork W1969784655 @default.
- W2127214059 hasRelatedWork W2007950744 @default.
- W2127214059 hasRelatedWork W2118390833 @default.
- W2127214059 hasRelatedWork W2138523529 @default.
- W2127214059 hasRelatedWork W2154758272 @default.
- W2127214059 hasRelatedWork W2170571577 @default.
- W2127214059 hasRelatedWork W2186060428 @default.
- W2127214059 hasRelatedWork W2285367795 @default.
- W2127214059 hasRelatedWork W2375012869 @default.
- W2127214059 hasRelatedWork W2406017067 @default.
- W2127214059 hasRelatedWork W2414585408 @default.
- W2127214059 hasRelatedWork W2487605797 @default.
- W2127214059 hasRelatedWork W2591330602 @default.
- W2127214059 hasRelatedWork W2891921925 @default.
- W2127214059 hasRelatedWork W3021065253 @default.
- W2127214059 hasRelatedWork W3082261404 @default.
- W2127214059 hasRelatedWork W3087637000 @default.
- W2127214059 hasRelatedWork W3122495802 @default.
- W2127214059 hasRelatedWork W3169159294 @default.
- W2127214059 hasRelatedWork W2186231585 @default.
- W2127214059 isParatext "false" @default.
- W2127214059 isRetracted "false" @default.
- W2127214059 magId "2127214059" @default.
- W2127214059 workType "article" @default.