FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2127218392> ?p ?o ?g. }

• W2127218392 endingPage "1673" @default.
• W2127218392 startingPage "1667" @default.
• W2127218392 abstract "Objective. Alkaptonuria (AKU) is an ultra-rare autosomal recessive disease that currently lacks an appropriate therapy. Recently we provided experimental evidence that AKU is a secondary serum amyloid A (SAA)-based amyloidosis. The aim of the present work was to evaluate the use of antioxidants to inhibit SAA amyloid and pro-inflammatory cytokine release in AKU. Methods. We adopted a human chondrocytic cell AKU model to evaluate the anti-amyloid capacity of a set of antioxidants that had previously been shown to counteract ochronosis in a serum AKU model. Amyloid presence was evaluated by Congo red staining. Homogentisic acid-induced SAA production and pro-inflammatory cytokine release (overexpressed in AKU patients) were evaluated by ELISA and multiplex systems, respectively. Lipid peroxidation was evaluated by means of a fluorescence-based assay. Results. Our AKU model allowed us to prove the efficacy of ascorbic acid combined with N-acetylcysteine, taurine, phytic acid and lipoic acid in significantly inhibiting SAA production, pro-inflammatory cytokine release and membrane lipid peroxidation. Conclusion. All the tested antioxidant compounds were able to reduce the production of amyloid and may be the basis for establishing new therapies for AKU amyloidosis." @default.
• W2127218392 created "2016-06-24" @default.
• W2127218392 creator A5007539736 @default.
• W2127218392 creator A5009683114 @default.
• W2127218392 creator A5018866927 @default.
• W2127218392 creator A5021170470 @default.
• W2127218392 creator A5033577513 @default.
• W2127218392 creator A5040388388 @default.
• W2127218392 creator A5047924664 @default.
• W2127218392 creator A5059584477 @default.
• W2127218392 creator A5060747268 @default.
• W2127218392 creator A5080730166 @default.
• W2127218392 creator A5087193878 @default.
• W2127218392 creator A5091423910 @default.
• W2127218392 date "2013-05-23" @default.
• W2127218392 modified "2023-09-23" @default.
• W2127218392 title "Antioxidants inhibit SAA formation and pro-inflammatory cytokine release in a human cell model of alkaptonuria" @default.
• W2127218392 cites W1974941490 @default.
• W2127218392 cites W2006165246 @default.
• W2127218392 cites W2026685126 @default.
• W2127218392 cites W2029143230 @default.
• W2127218392 cites W2035762801 @default.
• W2127218392 cites W2037308721 @default.
• W2127218392 cites W2039183762 @default.
• W2127218392 cites W2042056482 @default.
• W2127218392 cites W2059195164 @default.
• W2127218392 cites W2078759030 @default.
• W2127218392 cites W2085586735 @default.
• W2127218392 cites W2089472459 @default.
• W2127218392 cites W2093037213 @default.
• W2127218392 cites W2106353999 @default.
• W2127218392 cites W2115168835 @default.
• W2127218392 cites W2121389632 @default.
• W2127218392 cites W2126397496 @default.
• W2127218392 cites W2130995172 @default.
• W2127218392 cites W2170792683 @default.
• W2127218392 cites W2586876181 @default.
• W2127218392 cites W85642808 @default.
• W2127218392 doi "https://doi.org/10.1093/rheumatology/ket185" @default.
• W2127218392 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3741479" @default.
• W2127218392 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23704321" @default.
• W2127218392 hasPublicationYear "2013" @default.
• W2127218392 type Work @default.
• W2127218392 sameAs 2127218392 @default.
• W2127218392 citedByCount "41" @default.
• W2127218392 countsByYear W21272183922013 @default.
• W2127218392 countsByYear W21272183922014 @default.
• W2127218392 countsByYear W21272183922015 @default.
• W2127218392 countsByYear W21272183922016 @default.
• W2127218392 countsByYear W21272183922017 @default.
• W2127218392 countsByYear W21272183922018 @default.
• W2127218392 countsByYear W21272183922019 @default.
• W2127218392 countsByYear W21272183922020 @default.
• W2127218392 countsByYear W21272183922021 @default.
• W2127218392 countsByYear W21272183922022 @default.
• W2127218392 countsByYear W21272183922023 @default.
• W2127218392 crossrefType "journal-article" @default.
• W2127218392 hasAuthorship W2127218392A5007539736 @default.
• W2127218392 hasAuthorship W2127218392A5009683114 @default.
• W2127218392 hasAuthorship W2127218392A5018866927 @default.
• W2127218392 hasAuthorship W2127218392A5021170470 @default.
• W2127218392 hasAuthorship W2127218392A5033577513 @default.
• W2127218392 hasAuthorship W2127218392A5040388388 @default.
• W2127218392 hasAuthorship W2127218392A5047924664 @default.
• W2127218392 hasAuthorship W2127218392A5059584477 @default.
• W2127218392 hasAuthorship W2127218392A5060747268 @default.
• W2127218392 hasAuthorship W2127218392A5080730166 @default.
• W2127218392 hasAuthorship W2127218392A5087193878 @default.
• W2127218392 hasAuthorship W2127218392A5091423910 @default.
• W2127218392 hasBestOaLocation W21272183921 @default.
• W2127218392 hasConcept C126322002 @default.
• W2127218392 hasConcept C142724271 @default.
• W2127218392 hasConcept C185592680 @default.
• W2127218392 hasConcept C203014093 @default.
• W2127218392 hasConcept C2776151105 @default.
• W2127218392 hasConcept C2776255415 @default.
• W2127218392 hasConcept C2776743390 @default.
• W2127218392 hasConcept C2776914184 @default.
• W2127218392 hasConcept C2777169657 @default.
• W2127218392 hasConcept C2777633098 @default.
• W2127218392 hasConcept C2778004101 @default.
• W2127218392 hasConcept C2778690821 @default.
• W2127218392 hasConcept C2779491571 @default.
• W2127218392 hasConcept C2779951007 @default.
• W2127218392 hasConcept C2780829032 @default.
• W2127218392 hasConcept C2910060150 @default.
• W2127218392 hasConcept C2986274086 @default.
• W2127218392 hasConcept C31903555 @default.
• W2127218392 hasConcept C55359608 @default.
• W2127218392 hasConcept C55493867 @default.
• W2127218392 hasConcept C71924100 @default.
• W2127218392 hasConcept C98274493 @default.
• W2127218392 hasConceptScore W2127218392C126322002 @default.
• W2127218392 hasConceptScore W2127218392C142724271 @default.
• W2127218392 hasConceptScore W2127218392C185592680 @default.
• W2127218392 hasConceptScore W2127218392C203014093 @default.
• W2127218392 hasConceptScore W2127218392C2776151105 @default.
• W2127218392 hasConceptScore W2127218392C2776255415 @default.

• next