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• W2127223670 endingPage "1351" @default.
• W2127223670 startingPage "1351" @default.
• W2127223670 abstract "A rapid and simultaneous separation of cationic and anionic peptides and proteins in a glass microfluidic device that has been covalently modified with a neutral poly(ethylene glycol) (PEG) coating to minimize protein adsorption is presented. The features of the device allow samples that contain both anions and cations to be introduced from a central flow stream and separated in different channels with different outlets—all in the presence of low electroosmotic flow (EOF) imparted by the PEG coating. The analytes are electrophoretically extracted from a central hydrodynamic stream and electrophoretically separated in two different channels, in which pressure driven flow has been suppressed through the use of hydrodynamic restrictors. Having different outlets for the electrophoretic separation channels that are spatially separated from the injection enables coupling with further downstream functionalities or off-chip detection, such as mass spectrometry. A plug of charged analyte is hydrodynamically pumped to the sampling intersection and anions from the plug migrate electrophoretically toward the anode in one channel while cations migrate toward the cathode in the other channel due to suppressed EOF from the PEG coating. The separations presented here required less than a minute to complete and produced average separation efficiencies of up to about 3,500 plates from a separation length of 2 cm. The extraction efficiency of both cations and anions from the hydrodynamic stream is determined experimentally and compared with a previously reported model that was used to determine anion extraction efficiency. The extraction efficiency is determined to be 87% and 98% for the two sample mixtures analyzed, and the values predicted by the model are within 3.5% of the experimental data. It is anticipated that this basic approach for simultaneous separation of anions and cations with reduced EOF will be integrated into larger microfluidic systems because the design provides separate outlets that can feed downstream processes or linked to off-chip detection." @default.
• W2127223670 created "2016-06-24" @default.
• W2127223670 creator A5004913584 @default.
• W2127223670 creator A5013579709 @default.
• W2127223670 creator A5062525969 @default.
• W2127223670 creator A5090978582 @default.
• W2127223670 date "2010-01-01" @default.
• W2127223670 modified "2023-10-03" @default.
• W2127223670 title "Simultaneous separation and detection of cations and anions on a microfluidic device with suppressed electroosmotic flow and a single injection point" @default.
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• W2127223670 doi "https://doi.org/10.1039/b921914e" @default.
• W2127223670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20498885" @default.
• W2127223670 hasPublicationYear "2010" @default.
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