Matches in SemOpenAlex for { <https://semopenalex.org/work/W2127230263> ?p ?o ?g. }
- W2127230263 endingPage "139" @default.
- W2127230263 startingPage "123" @default.
- W2127230263 abstract "Freeze-fracture transmission electron microscopy shows significant differences in the bilayer organization and fraction of water within the bilayer aggregates of clinical lung surfactants, which increases from Survanta to Curosurf to Infasurf. Albumin and serum inactivate all three clinical surfactants in vitro; addition of the nonionic polymers polyethylene glycol, dextran, or hyaluronic acid also reduces inactivation in all three. Freeze-fracture transmission electron microscopy shows that polyethylene glycol, hyaluronic acid, and albumin do not adsorb to the surfactant aggregates, nor do these macromolecules penetrate the interior water compartments of the surfactant aggregates. This results in an osmotic pressure difference that dehydrates the bilayer aggregates, causing a decrease in the bilayer spacing as shown by small angle x-ray scattering and an increase in the ordering of the bilayers as shown by freeze-fracture electron microscopy. Small angle x-ray diffraction shows that the relationship between the bilayer spacing and the imposed osmotic pressure for Curosurf is a screened electrostatic interaction with a Debye length consistent with the ionic strength of the solution. The variation in surface tension due to surfactant adsorption measured by the pulsating bubble method shows that the extent of surfactant aggregate reorganization does not correlate with the maximum or minimum surface tension achieved with or without serum in the subphase. Albumin, polymers, and their mixtures alter the surfactant aggregate microstructure in the same manner; hence, neither inhibition reversal due to added polymer nor inactivation due to albumin is caused by alterations in surfactant microstructure." @default.
- W2127230263 created "2016-06-24" @default.
- W2127230263 creator A5001321776 @default.
- W2127230263 creator A5016831738 @default.
- W2127230263 creator A5029251110 @default.
- W2127230263 creator A5044078533 @default.
- W2127230263 creator A5086833930 @default.
- W2127230263 creator A5012413882 @default.
- W2127230263 date "2007-07-01" @default.
- W2127230263 modified "2023-10-14" @default.
- W2127230263 title "A Freeze-Fracture Transmission Electron Microscopy and Small Angle X-Ray Diffraction Study of the Effects of Albumin, Serum, and Polymers on Clinical Lung Surfactant Microstructure" @default.
- W2127230263 cites W1821552323 @default.
- W2127230263 cites W1911761083 @default.
- W2127230263 cites W1963712708 @default.
- W2127230263 cites W1964809614 @default.
- W2127230263 cites W1966101773 @default.
- W2127230263 cites W1967433758 @default.
- W2127230263 cites W1968237379 @default.
- W2127230263 cites W1969712718 @default.
- W2127230263 cites W1969918851 @default.
- W2127230263 cites W1970157213 @default.
- W2127230263 cites W1970654496 @default.
- W2127230263 cites W1971266259 @default.
- W2127230263 cites W1971305507 @default.
- W2127230263 cites W1971649325 @default.
- W2127230263 cites W1977246120 @default.
- W2127230263 cites W1983173993 @default.
- W2127230263 cites W1988390928 @default.
- W2127230263 cites W1991859893 @default.
- W2127230263 cites W1993255671 @default.
- W2127230263 cites W1994145570 @default.
- W2127230263 cites W1996694581 @default.
- W2127230263 cites W2004014972 @default.
- W2127230263 cites W2004586929 @default.
- W2127230263 cites W2008297857 @default.
- W2127230263 cites W2009555081 @default.
- W2127230263 cites W2011018453 @default.
- W2127230263 cites W2018102891 @default.
- W2127230263 cites W2022987581 @default.
- W2127230263 cites W2023534523 @default.
- W2127230263 cites W2023944813 @default.
- W2127230263 cites W2028250245 @default.
- W2127230263 cites W2032169846 @default.
- W2127230263 cites W2033007803 @default.
- W2127230263 cites W2033400463 @default.
- W2127230263 cites W2033856258 @default.
- W2127230263 cites W2035517802 @default.
- W2127230263 cites W2036797279 @default.
- W2127230263 cites W2038711709 @default.
- W2127230263 cites W2040079263 @default.
- W2127230263 cites W2040551725 @default.
- W2127230263 cites W2042611887 @default.
- W2127230263 cites W2046535870 @default.
- W2127230263 cites W2051212097 @default.
- W2127230263 cites W2053277394 @default.
- W2127230263 cites W2059571424 @default.
- W2127230263 cites W2061903286 @default.
- W2127230263 cites W2062472658 @default.
- W2127230263 cites W2062784059 @default.
- W2127230263 cites W2065831502 @default.
- W2127230263 cites W2071991384 @default.
- W2127230263 cites W2072073844 @default.
- W2127230263 cites W2072687905 @default.
- W2127230263 cites W2077124012 @default.
- W2127230263 cites W2077221283 @default.
- W2127230263 cites W2077645356 @default.
- W2127230263 cites W2078364270 @default.
- W2127230263 cites W2079180551 @default.
- W2127230263 cites W2080098587 @default.
- W2127230263 cites W2082578252 @default.
- W2127230263 cites W2083817873 @default.
- W2127230263 cites W2084692196 @default.
- W2127230263 cites W2085183303 @default.
- W2127230263 cites W2085326870 @default.
- W2127230263 cites W2085538885 @default.
- W2127230263 cites W2089109996 @default.
- W2127230263 cites W2090354115 @default.
- W2127230263 cites W2090819119 @default.
- W2127230263 cites W2092374904 @default.
- W2127230263 cites W2092521929 @default.
- W2127230263 cites W2094175235 @default.
- W2127230263 cites W2095868467 @default.
- W2127230263 cites W2099253666 @default.
- W2127230263 cites W2102770286 @default.
- W2127230263 cites W2106827654 @default.
- W2127230263 cites W2109121054 @default.
- W2127230263 cites W2110023782 @default.
- W2127230263 cites W2116344934 @default.
- W2127230263 cites W2119642205 @default.
- W2127230263 cites W2120938951 @default.
- W2127230263 cites W2121406265 @default.
- W2127230263 cites W2123419409 @default.
- W2127230263 cites W2125753556 @default.
- W2127230263 cites W2132976444 @default.
- W2127230263 cites W2133077619 @default.
- W2127230263 cites W2141800936 @default.
- W2127230263 cites W2142475957 @default.
- W2127230263 cites W2152311269 @default.