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• W2127253124 abstract "A new superoxide-generating enzyme, NADPH oxidase 4 (Nox4), contributes to osteoclastic superoxide production. In this study, we demonstrated that Nox4 is expressed at a higher level in osteoclasts than that in precursor cells. This result suggested that Nox4 is upregulated during the differentiation and development of osteoclasts. Cotransfection of Nox4/P22 DNA resulted in enhanced superoxide production in osteoclasts, indicating that P22 may be a necessary factor for the Nox4 activity. In addition, expression of both cathepsin K and TRAP is increased significantly in osteoclasts cotransfected with Nox4/P22. Further study revealed that JNK was activated and that NF-κB was inhibited in Nox4/P22 cotransfected osteoclasts. These findings suggest that superoxide and/or superoxide derived molecules may modulate the signal transduction pathways necessary for osteoclasts to function. © 2004 Wiley-Liss, Inc." @default.
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• W2127253124 date "2004-01-01" @default.
• W2127253124 modified "2023-09-25" @default.
• W2127253124 title "Expression of Nox4 in osteoclasts" @default.
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• W2127253124 doi "https://doi.org/10.1002/jcb.20048" @default.
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