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- W2127264078 abstract "FAP is an autosomal dominant condition with a prevalence of 1 in 8-10.000 births and is linked to a mutation/deletion in the Adenomatous Polyposis Coli (APC) gene on chromosome 5. The risk of colon cancer in untreated FAP approaches 100%. Thus, screening of at risk individuals is crucial. We investigated using DNA testing for FAP to reduce the frequency and cost of endoscopic screening of at risk individuals. METHODS: We computed the cost of annual colonoscopy performed in a hospital based endoscopy suite and an ambulatory endoscopy suite. The costs were derived from reported charges for professional fees, supplies, medications, nursing, room and pathology fees. We assumed that an individual underwent annual colonoscopy from age 10-25 yrs (a 15 yr screening period), as per the current recommendations. We then calculated the cost of a modified screening program by adding the cost of performing the current genetic test available for FAP to the cost of performing modified endoscopic screening for individuals who were negative for an APC mutation. The modified schedules included baseline colonoscopy, and then colonoscopy either every 3 yrs, every 5 yrs, or no further procedures. The total costs of these screening approaches were then compared. RESULTS: We demonstrated a considerable reduction in cost over a 15 yr period when an individual did not carry an APC mutation and when procedures were done in an ambulatory endoscopy suite. The cost comparison analysis over the expected 15 yr screening period is given in the table. CONCLUSIONS: There were significant cost savings when at risk individuals for FAP undergo DNA screening. We speculate that utilization of genetic testing for FAP will result in improved patient acceptance and participation in a screening program." @default.
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- W2127264078 date "1996-10-01" @default.
- W2127264078 modified "2023-09-25" @default.
- W2127264078 title "21 COST-EFFECTIVENESS OF DNA TESTING VS SURVEILLANCE COLONOSCOPY FOR FAMILIAL ADENOMATOUS POLYPOSIS (FAP)." @default.
- W2127264078 doi "https://doi.org/10.1097/00005176-199610000-00051" @default.
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